The high Wei factor of mammary glands cancer

In addition to parts of hereditary mammary glands cancer outside, great majority mammary glands the outbreak of the cancer can't use a certain cause of disease hermeneutic, but outside inside the body various high Wei factor the result of the function.



Household history with related gene



Has the its occurrence mammary glands cancer of American women that a class relatives suffers from a mammary glands cancer all a rate to compare have no household history of Gao 2~300%, if one class relatives at unique through ago suffer from a pair of sides mammary glandses the words of the cancer, it the opposite and dangerous degree is up to more 900%.Be showed from this, the mammary glands cancer household history is an important dangerous factor.



Sometimes the mammary glands cancer can express the characteristic which gathers together for the household, namely at least 3 relativeses in paternity or matriarchal society suffer from a mammary glands cancer, have mammary glands cancer and the ovary cancer household history in the meantime, there are a pair of sides cancerous with earlier period mammary glands(or) of household history.Generally speaking, the household gathers together a sexual mammary glands cancer and can is divided into two kinds of formation mechanisms:1 kind is to cause the mammary glands cancerous occurrence because of the change of various genes;Another then because of some one single shot because of mutation but take place of hereditary mammary glands cancer.The research of the United States think that only 5% mammary glands cancers with 10% ～s from a certain heredity the gene mutation cause of, if suppress cancer gene p 53.Other mammary glands cancers related gene still have BRCA － 1 is 2 genes with BRCA － .Have already confirm in 45% hereditary mammary glands the cancer with 80% mammary glands cancer companion ovary the sufferer of the cancer to there is BRCA － the mutation of one gene currently.Another research shows that the women who have BRCA － one gene mutation take place a mammary glands cancer all a rate for 50% at the age of 50, and go to at the age of 60 it all the rate can increase to 80%, in the meantime its ovary cancer of the incidence rate also obviously increases.BRCA － 2 clinical meaning and BRCA － of gene mutations be one likenesses, but with the ovary cancer take place of the relativity be not big.



Grow a factor



The women's mammary glands is subjected to function growth of ovary hormone in the awkward age mature, but the mammary glands cell be subjected to the hormone in the monthly body periodic variety and gestation of the level to expect the hormone in the body level of go up but take place to living reasonableness of increase and living change.This kind of cell propagates a partite form at the women extremely through terminate.The occurrence of the mammary glands cancer with above-mentioned of the variety grow a factor to have near concern.



1)the menarche age of the menarche age the little women suffer from mammary glands cancer of all rate old, but most researches hint, menarche age with unique through front with unique through empress of mammary glands cancer all relevant fasten.Press experience in the United States, the menarche age postpone 1 year old, its mammary glands cancer of the dangerous degree reduce 20%.The menarche age youngly teaches age period women, it the hormone level in the body be higher, but the menstruation period be shorter, so expose in inside the degree within environment of the source sex hormone more big, this may be the main reason which results in this part of women easily suffer from a mammary glands cancer.



2)stop menstruating the age stop menstruating currently night's being the dangerous factor of mammary glands cancer have already been confirm, according to the United States of data, stop menstruating to postpone for a year each time, increases mammary glands cancer of all rate is 3%.Regardless is a menarche early still cut off through night, actually was the women's menstruation history to prolong.Have the data report the way, 40 years above menstruation history than 30 years following menstruation history occurrence mammary glands cancer of all the rate increase 100%.



3)the length of the menstruation period of the menstruation period also more and with one accord thinks to be one of the dangerous factors of mammary glands cancer currently.The research discovers 20~39 yearses to take place the risk of mammary glands cancer by the period short women big.This may be because of short menstruation period Huang2 Ti3 Qi2 of be opposite and longer, but estrogen and Yun hormone at yellow body mid-term all is high level.The menstruation period is longer, regardless whether rule, will lower the risk of mammary glands cancer.



4) the first foetus foot month gestation age a great deal of Epidemiology investigate to discover and have never taught the risk that the women suffer from a mammary glands cancer and compared to once grow of women big, and women the first foetus the normal gestation age be more young, she suffers from mammary glands from cradle to the grave cancer of all the rate be also more small, but the difference main body of these risks be 40 years old to will diagnose to is cancer for mammary glands hereafter now of in the women, rather than young mammary glands cancer patient.Because the foot month gestation can cause for for the first time mammary glands top skin occurrence a series variety but tend mature, but the last skin cell of mature empress has stronger nti- gene a mutation ability.



5)produce a research discovers Gao Chan3 Ci4 of women's suffering from a mammary glands cancer all a rate be allsm.



6)the breast feed history didn't breast feed women to easily get a mammary glands cancer.The occurrence of this physiology and mammary glands cancer which matches mammary glands learn, can explain a mammary glands cancer the region of the incidence rate the phenomenon of the difference in the meantime.



Sex hormone



The mammary glands cancer dangerous factor much has hypostatic contact with sex hormone level inside the body, but animal experiment is also confirm the sex hormone can help the mammary glands cancer to take place of standpoint.



1)the estrogen research discover, unique through empress in the women suffer from inside the mammary glands cancer more healthily female body always estrogen level average high and 15% ～ss be 24%s.The women carry on estrogen to act for therapy because of various reason after stop menstruating, but many researches discover and add the outside source estrogen will increase an opportunity of suffer from the mammary glands cancer.



2)the male hormone male hormone increase mammary glands cancer of the risk produces result again after can pass the function that the direct Cu mammary glands cancer cell propagate and indirectly pass the conversion as estrogen.Greatly part of researches really confirmed to cut off through empress women the positive relativity of male hormone level and mammary glands cancer risk inside the body.



3)urge the milk plain animal experiment and a great deal of foundation research to hint, urge a milk vegetable cancerous to the mammary glands of the occurrence has already promote function, Gao level of urge a milk vegetable will increase the risk of mammary glands cancer.



4)other hormone insulin kind growth factor(IGF － 1) and its mainly combining egg white IGFBP's －'s 3 relations between levels and mammary glands cancer have already been been several Epidemiology to study of the Ba order, and show them with mammary glands cancer of the outbreak have positive relativity.But female three Chuns and Yun Tong then is think by most scholars to protect a function.



Nourishment and food



1)the fat have a proof manifestation with hot quantity food, the increment of the weight has relation with mammary glands cancer, particularly at unique through after.Mammary glands an inquisition of Shanghai City shows that women's type of figure becomes gradually the opposite and dangerous degree of the cancer of the fat mammary glands increment, take about 60 years old women as very, increase 10 kilograms weight, cancer of the risk will increase 80%.Moreover, young period hot quantity the food make growth growth to accelerate and the menstruation advance and cause thus the increment of the middle age later weight, end will increase the occurrence of mammary glands cancer.



2)ether according to report way everyday drink alcohol the more than 3 of women suffer from the dangerous degree of mammary glands cancer to increase 50% ～s 70%.



3)the cellulose cellulose all has already repressed a function to the mammary glands cancer and the large intestine cancerses and the research discovers the women of little food vegetable suffer from the risk of mammary glands cancer a light degree increment.The cellulose which absorbs in the meal increases 20 grams till everyday and the risk of mammary glands cancer will lower 15%.



4)micronutrient experiment the research discover the vitamin A material having protection function to the mammary glands cell.Foreign report way, soybean egg white and it the important composition soilbin obviously repressed a mammary glands cancer the function of the occurrence.



Other environment factors



1)the electricity leave radiation emanation, the line probably hurts the DNA of machine body, particularly at the teenager is period.The mammary glands cancer outbreak rate has already increased high trend in Japanese Nagasaki and wide island atomic bomb the explosion the hour of the luckily survive;The postnatal period mastitis accepts women who project the treatment and because of thymus gland enlarge but go emanation treatment of baby girl, hereafter mammary glands cancer of the outbreak rate also increase Gao.Expose in project linear ge more young the risk be more high.The outbreak of mammary glands cancer has something to do with give or get an electric shock leaving radiation, so someone put forward the mammary glands X line and the census probably increases the risk of mammary glands cancer.



2)the treatment medicine of the medicine chemistry at the time of curing tumor, it also has a cancer-causing function.Among them, the alkane turns and can induce various entity lumps and include the occurrence of mammary glands cancer.Moreover, various medicines which cure high blood pressure include benefit to give up even, Fen Mao Shi, A Ji many Bas have increment to urge with three wreath analgesics milk vegetable secrete of function, as a result the risk of the cancer of the possible increment mammary glands.A little bit another medicine, such as department Lin2 Deng3 not the steroid anti- burning medicine be confirm have to repress the function that the large intestine cancer take place, someone discovers that they equally have to lower a mammary glands cancer the function of the risk.



3)the athletics toughen 40 years old appropriate sport canned reduce the risk of mammary glands cancer before, the estimate taught an age women the athletics for 4 hours to toughen every week not more toughen of women's risk reduces 60%.



4)occupation research's result show, be engaged in the women of occupations, such as hairdressing industry and medicine manufacturing...etc. mammary glands cancer of the risk go up.



Disease factor



Some diseases will increase the risk of mammary glands cancer and among them, what to have a representative most be 2 diabetes.Moreover, insulin level inside the body and sex hormone combine globulin level to present negative related, so the high insulin level will cause high estrogen and male hormone level in the meantime.