The Chinese single anti- medicine:The industry turned to just start

The market foreground of single anti- medicine is vast


The single anti- medicine cures realm to have advantage in the tumor.The medicine profession information provides the company with the IMS company to lately announce of data express, global market quota of the tumor medicine has already come to an USD 28,500,000,000 in 2005, occupied the whole 5.1% of medicine market in the world, together compared to increase 18.6% with 2004 and Be thus come increasing a quickest species in ten big medicines in the worlds.In the sale the composing, the specific weight that the cell toxicity medicine have is up to 45%, but single nti- type the Ba then distinguishes to 30% and 25% toward the specific weight of the medicine and the hormone medicine.Speak from the curative effect, single nti- type the Ba exists clinical advantage toward the medicine.


First, it can according to gene mutation characteristic to classify normally and not- normal cell and protein, and optionally attackstone to repress a tumor cell growth, make thus the whole tumor treatment the process become more efficient and lowered a medicine toxicity, indiscriminately attackstone all cells to become fresh and clear contrast with the cell toxicity medicine.


Secondly, the single nti- medicine's ability is different degree extension tumor the sufferer exist time, this to tumor treatment to speak to have very important meaning.Although compared with the traditional cell toxicity medicine, the single anti- equally treats distance expenses to show Zhao to go up, among them, the song secure bead single anti- is many west yew Chun of 300%, the Ao sand benefit platinum of 8.900%.But the tumor be the cause death of severity sex disease, the single anti- can prolong vital curative effect to make the tumor sufferer's sensitive to the expenses degree to show Zhao to descend, and the sufferer separate a period of time and have to again use a medicine, the market foreground of the single anti- amplitude.


Single anti- medicine's transplanting realm in the organ has already had a certain market.The whole world about carries on 20,000 organs to transplant annually, because the organ transplantation is an expensive surgical operation, the liver transplant perhaps kidney transplantation's costing several 100,000 dollarses be very familiar, single nti-20,000 dollars the or so expenses be insignificant;And have already become because of the good function of single anti- a glimmer of use a medicine, single anti- medicine's transplanting the position of realm in the organ has already build up.However, is still the crux that the single anti- expand in the disease realm of the oneself immunity, need and expenses.


The foreign single anti- medicine profession growth is fast fierce


The sale sum of global antibody medicine is only USD 1,200,000,000 in 1999, soar to USD 10,500,000,000 in 2004 and have a global medicine market 2% of the quota around.(figure 1)Under the push that match a body, person's source to turn complete person's source to turn from the Qian antibody's etc.'s a series of technique develop anticipate global in 2010 antibody medicine year sell a sum and can attain USD 30,000,000,000.Can say, the antibody medicine has become one of the most important big types in the medicine of living creature technique.




The 2002-2005 years global main single anti- always sells sum and growth rate(picture source:《New wealth 》)


Currently, in addition to the American FDA grant of 23 kinds of antibody medicine, still have 120 various antibody medicine to be placed in a clinical development stage in the meantime, 500 varieties be placed in clinical ago develop a stage.According to the investigation report of the United States-made medicine company's association(PhRMA), the single anti- occupies the comparison of living creature medicine of be placed in the clinical research stage from 20% of 2002 and 23% of 2004, rise to 34% in 2006 and expressed a single gram Long antibody the medicine will occupy a more and more important position.BE sell a market, 2004 world adds up to 22 single gram Long antibody medicine to appear on market sale, sell a sum to amount to USD 10,300,000,000 and share the treatment egg white medicine a market sale a sum of 18.7%.But of the single anti- medicine divide very obviously, two ex- English benefit Xi single anti-, benefit secure Xi single anti-s totally occupy 57% market quotas, 8 kinds of ex- sale sumses biggest single gram Long antibody the sale sum of the medicine come to an USD 10,100,000,000 and share a single gram Long antibody is 98% of the medicine market, but surplus 14 kinds ofs share a single anti- market of 2%.(figure 2)




The 2002-2005 years global main single anti- sells a sum(picture source:《New wealth 》)


Produce technique and funds need is single nti- professions the biggest hard nut to crack


To single anti- medicine, strong because of aiming at sex, develop the risk that the clinical research fail smaller, but produce a technique is one of single anti- profession main barracks.First, true pit the antibody in the cell express the quantity be lowly to not yet solve.A lot of local laboratories, true pit the antibody expression in the cell measure below 1 mg/L, can hardly used for production.Only individual laboratory antibody expression the quantity attain a 60-100 mgs/L, but at flourishing nation, average the amount of expression of the antibody be or so in the 2000 mgs/L.Secondly, local mammal cell development's enlarging a craft hasn't solve.Single gram abroad Long antibody the medicine produce to generally and all use a 2000-10000 Ls and even the 15000 Ls ferment a bottle of production.But the Chinese development scale of the animal cell be widespread following in the 80 L, antibody and vaccine production attain a 500 Ls separately and foster a way to mostly adopt tiny carry body development, infuse to flow and flow to add development industry chemical engineering a skill in a row still in the formation.


Funds is also get into single anti- medicine manufacturing industry of main barracks.To medicine manufacturing business enterprise to speak:Single anti- profession fixed assets devotion Gao-in 2006 global production type animal cell development reactor of total scale is 1,970,000 Ls, mammal cell expression of the egg white is total the yield be about 3800 kilograms.The production ability of the global reactor also only 2 grams of egg white medicine/rise a reactor, can attain a world to normally sell of single nti- year the average yield at least attains 20,000 grams, turn over to reckon and then need at least 10,000 rise the development reactor of the animal cell, fixed assets beginning start devotion to need USD 100,000,000.Speak to the sufferer, lead high fixed assets devotion to make to produce a gram of the cost which reorganizes egg white in above USD 2000, some even attains USD 5000 and cause from here medicine price expensive, will test the sufferer's acceptance ability.


Local and single anti- profession just start


The local antibody medicine market is three battlefields of the property brand product conflicts, unique have a domestic species to appear on market of is a rat anti- person T lymphoid cell CD3 antigen single gram Long antibody, the local business enterprise produce of that product isn't enough 1% at the quota share by the whole antibody medicine market, other competition products all is importing species.From the domestic in 2005 single nti- sale sum to see, single anti- market distributes in the anti- tumor and the anti- to transplant a rear row difference to respond two greatest realms, the anti- tumor medicine have compare 61.2%, among them, the benefit secure Xi single anti- get soldier's thing and share all single nti- sale a sum 49.1% quotas;Anti- row difference reaction the medicine have compare 38.8%;Reach to a gram of anti- with single bead and the single anti- of Ba Li4 Xi2 to have among them higher.But at global the situation excels on the market the English benefit Xi single anti- of the benefit secure Xi single anti- didn't see a trace, this had something to do with its treatment disease grow, English benefit Xi single nti- treatment rheumatism arthritis, because antibody medicine the price be high, Johnson's company thinks a type of rheumatism arthritis etc. the disease grow of the sale sum mainly relates to citizen's income and they didn't get into a Chinese market.