【All say 】
The cancer is swollen to the indirect function(remote effect) of sufferers' nervous systems cause of symptom, also call that the side of the tumor is usually comprehensive to advertise for(paraneoplasticsyndromes), present progress, occasionally self-moving alleviate or after the tumor is take off divided by but alleviate.Companion hair the total outbreak rate of the cancer originates various tumor of net cell as 2% for 6% at various last skin cell, bronchus lung cancer, ovary cancer of the incidence rate be higher, be up to 16% and 11% respectively, but rectum cancer and the incidence rate of cervical cancer be lower.
【Be taken bad a mechanism 】
The accurate outbreak principle hasn't clarified currently.The cancer swollen toxin, infection, metabolism mess and nourishment obstacle, all once was think is possible with the result that the cause of disease was plain.In recent years, some authors because of discovering existence's antibody for nervous system in some patients blood circulation think the abnormality that this disease responds with oneself immunity or immunity relevant, and find out antibody from the cancer swollen pathological changes sufferer's serum and brain ridge liquid of the sex sensory nerve.Someone think the cancer is swollen to produce much more some Maos, but these many Maos have a function of repress the immunity mechanism.The some cancerses are swollen(such as lung cellule don't cent type cancer) to produce to have a type of material with live living creature of cortisone, a little bit another cancerses are swollen and can cause blood calcium to increase Gao, blood sugar to lower, anti- benefit urine hormone increment, so calculate a cancer swollen with the result that of metabolism mess, may also relate to the occurrence of this disease.In fine, the outbreak mechanism of the cancer swollen sex nerve muscle pathological changes, may fasten various comprehensive factors with the result that.But different outbreak mechanism, may also the ability relate to following and a few different types.
【Clinical performance 】
Cancer swollen sex nerve-muscle the symptom of the disease can at discover before cancer is swollen, after or simultaneous with.Its course of illness and serious degree and the cancer swollen size and growth speed are uncertain parallel.Each part of nervous system can in the meantime or successively implicate, the classification of precision is more difficult.Advertise for according to its main symptom and body, is divided into several following category type.
(A)brain pathological changes
1.the second impatient cerebellum skin quality change sex cerebellum skin the quality fill the air sex to change sex, takes purkinje cell as obvious.Dentation pit, brain stem of eyeball sport pit, olives pit, skin quality the cerebellum tie and the spinal cord cerebellum tie and the awl body tie to also often implicate.The CT scan, or the MRI can show that the cerebellum atrophy.Deliver a cancer at first swollen take lung cancer as to much see, secondly is ovary cancer, mammary glands cancer...etc..Second impatient disease, the performance is totally a pair of body with symmetrical sides to help out of tune, among them with tread Tai hobble, the Gou sound obstacle, speech shout to eat for familiar, can have already faint or reply to see, the eyeball tremor then not and all has.The brain ridge liquid protein and lymphoid cell content increase Gao.Transfer sex cancer with cerebellum swollen discriminate, lie in this disease to advertise for for the symmetry sex body, have no Lu inside press to increase Gao.The hereditary cerebellum become the sexual course of illness is far slow-moving, but this disease fasten second impatient, develop more and quickly, can distinguish.With alcoholism the cerebellum is comprehensive to advertise for of discriminate BE:This disease totally helps sport influence to the arms more heavy, and the speech shout to eat to show Zhao more.
2.the side slow encephalitis clinical main performance is Alzheimer's Diseases, pathology change it is thus clear that inside brain hemisphere extensive nerve cell disappear, the companion have blood vessel surroundings the lymphoid cell accumulate to gather, especially in the Nie leaf's seamy side and the Qiu brain.Rise the disease concealed set of, start express to suppress Yu for the worry anxiously, make progress gradually for stupid, the near matter remembers obvious obstacle, the affection inconstancy turn, intelligence decrease, the earlier period of pathological changes namely has an EEG abnormality, sufferer brain ridge the lymphoid cell and the protein content in liquid can light degree increment.
3.brain stem brain disease of the companion has a stupid brain stem function obstacle, concealed set of or second impatient disease, gradual progress.The brain stem damaged symptom and body advertise for:Faint, eyeball tremor, swallow obstacle, eye muscle to paralyze, total help out of tune and male Babinski to advertise for.The pathologic change primarily focused on descend bridge brain and postpone Sui, it is thus clear that the nerve cell disappear, there is blood vessel the surroundings lymphoid cell set.
4.look awry eye the Lyuan(opsoclonus) be a kind of more seldom seen cerebellum to synthesize to advertise for and exercise for the eyeball that the self-moving, total yoke disorder.More serious when the eyeball at will exercises, often the companion have cerebellum to totally help the muscle of maladjustment and torso, body Lyuan.This is comprehensive to advertise for more familiar in the child of become the nerve cell lump the sufferer.Applied adrenal glands skin quality hormone, or the tumor then have an amendment after being cure.
(Two)spinal cord pathological changes
1.second impatient and bad dead spinal cord disease pathology the variety take ash quality and white quality obviously bad dead of spinal cord as a characteristic, win chest segment the spinal cord implicate for most serious, often involve in several stanza segment.Express for second impatient rise to get sick of intersect sex spinal cord damage.The pathological changes can quickly rise and involve in neck Sui, then quadriplegia, have already spread a different bunch the type felling obstacle and the function obstacle of the urine bladder rectum.Most sufferer condition severity, often with in the week die in few day or number.Often there are protein increment and white cell increase in the brain ridge liquid, mostly the companion hair is at the lung cancer, lymphoid lump and the leukemia.
2.motor nerve dollar the disease pay respects to 467 sections"motor nerve dollar disease".Clinical symptom and muscle atrophy the sex side Suo cirrhosis likeness, see swollen at various cancer, particularly is a lung cancer.Some case companions have a light degree felling obstacle and contribute to discriminating diagnosis.
(Three)surroundings nerve pathological changes
1.deliver sex end mental derangement more since the disease usually is second impatient, is take place in lung cancer sufferer more, pathology change with the end nerve change sex is most obvious, decrease and muscle of the muscle dint with symmetrical body atrophy, Jian glint disappear, the arms and legs bitter end presents gloves socks a type a felling a decrease.A handful of patients can alleviate by oneself.The tumor of these case chaperonages may be the original cell lump of the Huo hero's gold surname disease, Jing or malignant parotid lump.
2.the second impatient sensory nerve disease be often second impatient disease, arms and legs depth felling obstacle, felling decrease, felling abnormality, to the body muscle dint is without the obvious influence then.Jian glint decrease or disappear, have a felling to totally help out of tune.The protein content often increases Gao in the brain ridge liquid and the lymphoid cell increase.
3.the acute delivers sex nerve root more the mental derangement calls GuillianBarre again'comprehensive advertise for.Much take place at the lymphoid lump sufferer.(pay respects to "lymphoid lump")
4.other.
(Four)muscle disease
1.the Eaton-Lambert muscle have no dint comprehensive advertise for and call a type of advanced case muscle have no dint comprehensive advertise for.It is see in male(have 70%) more, deal with contact the chronic disease of function obstacle for the nerve muscle.Can for lung cancer of the earlier period express, most is oaten cell type bronchus lung cancer.The clinical symptom is mainly near for body to carry and the torso muscle have no dint, emaciated and easily tired, muscle outside the eye with postpone the Sui muscle implicates just occasionally.The sufferer often tells a companion to contain pain and body felling abnormality of the thirsty, impotence, .Can discover that the nerveless muscle is after start the constringency several kind while check, its muscle dint can temporarily increase, but time be slightly long after namely appear abnormal state tired.The muscle Jian glint often dies down or disappears.Most patients responded with"the Teng pleased dragon(tensilon)" to"new Si of clear", or only had weak reaction.The E.M.G. shows to induct electric potential increment, this just has no dint with advanced case muscle the sufferer be contrary.Have certain curative effect with the ammonia Ji Mao Ding(aminopyridine) to the hydrochloric acid Gua(Guanidine hydrochloride), the blood plasma displacement cure also probably valid.The lung cancer after cut off parts of patients symptom can alleviate.Nerveless with advanced case muscle discriminate can make reference to table 24-5.
2.the advanced case muscle has no dint 10% companion hairs are at the thymus gland lump.(pay respects to "advanced case muscle have no dint")
【The diagnosis explain 】
The cancer swollen sufferer appears nerve symptom and need to discriminate to fasten a cancer swollen transfer or fasten companion hair swollen nerve-muscle a disease at the cancer.Usually cancer swollen sex nerve-muscle disease's doesing not appear to press to increase Gao or spinal cord inside Lu be press of clinical advertise for elephant, the suspected case needs to make various assistance check.If appear nerve symptom first, especially at middle age above patient, its nerve symptom can't use single a focus an explanation again, for example, have in the meantime merge of the cerebellum symptom eyelids a bottom to hang, body felling symptom and muscle atrophy, should carry on a necessary system check, in order to detection may latent cancer swollen cooking stove.In addition discover nerve symptom in accept put treat, the chemotherapy the cure the person, still need with project the disease(for example radio spinal cord disease), chemotherapy complications mutually discriminate, and should notice to have have no the hair infect and organ metabolism influence after injure.
【The treatment explain 】
The most is to cure for good to deliver a cancer at first swollen.Deliver a cancer at first swollen after cut off, a part of nerve muscle diseases may have to alleviate.The skin muscle is burning and deliver sex muscle more burning, surroundings mental derangement, application the adrenal glands skin quality hormone treatment, probably valid.The muscle has no dint comprehensive advertise for can use the Mao medicine of the anti- Dan alkali fat, if effect not obvious, then can change to use hydrochloric acid Gua(guanidine hydrochloride), it in common use quantity is everyday 15~40 mgs/kg, separately four times take orally.This medicine has certain influence to the myocardial, should not take over a long period of time.
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