The heavy ion beam puts to treat a research to get close to "the cancer be evil" directly and quickly

In November, 2006 up to now in March, year, the modern physical graduate school of the Chinese science, hospital and the state total hospital of the orchid state military district orchid, sweet tumor hospital in the Su province etc. the tight Luo airtight drum ground of the medical treatment unit openned an exhibition 3 tumors heavy leave son to tie a treatment clinical trial, make our country become after the United States, Japan, Germany, the fourth in the world open the exhibition heavy ion beam anti-cancer clinical trial study of nation.And, pleased BE, 28 sufferers after heavy ion beam projecting a treatment, the beginning sees result.The relevant expert who participates a research point out that heavy ion beam currently drive generally accepted in order to be to ideally put to treat to shoot one of the lines for 21 centuries, many nations poured into a great deal of manpower and material resources to carry on a heavy ion beam to put a research of treat the technique and equip in the world in recent years, but our country of related the research has been follow close behind international develop a step.

Hoped to break normal regulations to put to treat to limit

According to the covariance, currently cancer cure by different method sufferer 5 year, the livability equally reaches to above 45%, be close to 40% to pass by to project treatment among them.However, worthy of pay attention to BE, the normal regulations emanation cures to treat to adopt for long time of the electron beam, X shoot line and γ to shoot line etc., although have better curative effect to some tumors, and project treatment equipments to design tight, because of the blemish of its physics and biology characteristic, normal organization and organ of tumor surroundings are still subjected to the equal irradiation for measure.The normal organization(especially to project line sensitive of important organization and organ) of tumor surroundings in order not to is harm by Sun, sometimes have to reduce total amount of, however so will cause the cure rate lower.American every year has 100,000 cancer sufferers to cause because of the partial tumor not yet gets control after project treatment treatment failure.

For breaking this to limit, the medical science field starts target vision a heavy ion beam treatment.The relevant expert introduce, heavy ion beam treatment cancer, have a series of advantage on the physics and the biology:While being the depth amount of distribute like.The energy of loss is smaller on its passage when the heavy ion pierces through Ba material, as a result can become a ping area of opposite low doses;But at close its artillery range bitter end will become a Gao Ji4 Liang2's energy loss Feng(Bragg Feng).The Bragg Feng of the energy convertibility passed to regulate to tie to flow makes a heavy ion beam Bragg Feng fixed position thus area at the tumor Ba in the position in the body, and can according to the thickness exhibition breadth Bragg of the tumor Feng, the realization is to the even irradiation of tumor Ba area.Two is that the energy deposition scope is more accurate, quantity the edge be clear and be advantageous to a precision treatment.(millimeter quantity class)Three is to spread the ability line density(LET) Gao, can raise to lack the emanation sensitivity of oxygen cell inside tumor.Four is to make use of the take of heavy ion electricity, can pass to scan magnetic iron to lead to tie to flow, make it break the shape of layer to by the square carry on irradiation according to the tumor, attain a proper form with adjust a strong treatment.Five is the applied positive electron blast-off breaks a layer be like(PET) device can monitor pit reaction an outcome of the positive electron annihilate radiation and carry out on-line supervision.Six is the opposite biology effect(RBE) of the area of Bragg Feng Gao, be advantageous to efficiently killing cancer cell of put out the Ba area.Seven is when the Bragg Feng area cell cause death an effect to almost be free from a cell period mutually of influence, namely the cell expects to radiate anti- sex disappearance after have the silk abruption the period of the DNA synthesize(S) to expect and express to together have the silk abruption the period cell almost similar radiation sensitivity.

The related and clinical research is widely valued

According to understanding, the Lawrence elder brother of one's father of the United States gram the benefit laboratory(LBL) makes use of its Gao first at 1975 per annum rates can the synchronously heavy ion accelerator(BEVALAC) carry on the clinical research that the heavy ion beam cure.To 1992, it accepts to cure of various cancer sufferer reach to 2487.Though at that time tied flow go together with send system and treatment system not perfect, for make selection of tumor, to compare with electron beam, X, the partial control rate shot line and γ shoot line etc. the treatment raised 2-300%, cure rate obviously raise.The LBL follows related sufferer to grind to investigate to still continue.

Japan is in the national in 1993 project the medical science comprehensive graduate school(NIRS) to build up heavy ion to cure to use to add a machine(HIMAC) soon.To the end of 2006, that organization treatment tumor is sufferer's more than 3000 and the 3 years partial control rate is more than 67%.Among them, head neck tumor of 3 years partial control rate more than 61%;Lu bottom lump 3 years partial control rate more than 92%;Lung and liver cancer 3 years partial control rate more than 72%;The 3 years partial control rate of prostate gland cancer is 100%.The Japanese government accepts in November, 2003 and admit the heavy ion beam anti- cancer is the medical treatment technique of a kind of height forerunner, plan in that country to build 60 heavy ion beam treatment center and make the Japanese cancer sufferer be subjected to a benefit at the heavy ion beam treatment.

In 1996, heavy ion research center(GSI) in Germany is built up.The GSI drew lessons from the treatment characteristics of the heavy ion beam of the United States and Japan and cure experience, develop and applied the forerunner's grid net to scan a bunch to flow to go together with to send to system and PET to cure a quality control to wait two greatest techniques means and come to an a heavy ion beam to adjust a strong emanation treatment and tie to flow solid hour on-line supervision.Come to a 100% to two kinds of Lu bottom the two years partial control rate of the example of 50 for each disease of the lump because of the GSI in 2002, the German government department concerned distributed to cure these two kinds of permits of cancers with the heavy ion beam and make the heavy ion beam cure the Lu bottom ridge Suo lump and grain form tumor to treat to become formal treatment means in Germany.The GSI is develop more heavy ion beam treatment an orientation a certificate currently.

In addition, some nations which own heavy ion accelerator, in the same way country, Italy, and so far didn't°yet the nations of heavy ion accelerator, such as Belgium, Switzerland, Austrian etc., also set up to sign a heavy ion beam treatment organization in the ferment.

At the beginning of 90's in 20 centuries till now, Chinese science, hospital modern physics research place our country the initiative openned an exhibition a heavy ion beam to cure the foundation research of cancer technique and successively undertook a nation"95" climb plan, national natural science fund point item, national high technique research development plan, medium more than ten topics such as section hospital and department class in the province point etc., carry on a heavy ion beam radiation physics, radiation the biology study and the animal test, acquired 1 to have importance value of the heavy ion beam cure a cancerous foundation data.

In September, 2000, the science meeting of the 145th-time Hsiangshan convened in organization in the Chinese science, hospital up, more than 30 scientist and expert of different academics through thorough consistently think after the discussion, heavy ion beam's curing a cancer is most nowadays to project under medical treatment science, first enter, the most superior anti-cancer means;Heavy ion beam anti- the development of the cancer is measure a national emanation to cure whole level whether get into international ex- row of important mark ambition;It of the clinical application will not only influence to put to treat realm, but also will also arouse a related science technical big development;Our country's developping a heavy ion beam anti-cancer condition has been mature.On these grounds, the experts put forward a suggestion toward the national department concerned:With the orchid state heavy ion research equip(HIRFL) for rely on, as soon as possible in the Chinese science, hospital modern physical graduate school establishment"the national heavy ion beam cure cancer science research center" with promote our country the development of heavy ion beam anti-cancer research;Support the modern physical graduate school of the Chinese science, hospital makes use of existing HIRFL heavy ion accelerator to increase to set up heavy ion beam anti-cancer device and carry out a heavy clinical trial research of the ion beam treatment of shallow form tumor as soon as possible;Support the modern physical graduate school of the Chinese science, hospital applies for national important science engineering and cool off storage wreath(HIRFL-CSR) in the orchid state heavy ion accelerator up establishment human body deep department the heavy ion beam treatment of the tumor equip.

Our country related treatment research the progress make the person encourage

Support strongly in the national department concerned under, two years, Chinese science, hospital modern physics research successfully develop a shallow layer tumor a heavy ion beam a treatment a clinical trial research device, and with medical treatment unit together drew up a clinical treatment experiment the standard of research, built up sweet Su to save a heavy ion beam a treatment tumor clinical research base.

In November, 2006, Chinese science, hospital modern physics research the place its independence innovation develop of shallow layer tumor heavy ion beam treatment equip up, 4 cancer sufferers who accept to cure to the state total hospital of the orchid state military district orchid for the very first time carried on small after 1 of the skin next 1.5 Li rice tumor treating a distance clinical trial treatment, result invite treating a distance for 10 days the tumor has already contracted 40%-60%.In January, this year, they again to sweet Su province tumor hospital and the state total hospital of the orchid state military district orchid accept to cure of 10 sufferers carried on small at the face of the skin next 2.5 Li rice tumor bed treatment.This time research the personnel was appropriate to raise the treatment radiation of everyday quantity, at about treat a distance for 8 days after the tumor has already contracted 40%-60%.This twice heavy ion beam cures the overwhelming majority sufferer of cancer clinical trial is through surgical operation, chemotherapy and other project therapy(the X line, γ shoot line and electron beam to cure) without the effect of sufferer.The whole treatment process didn't adopt any medicine assistance treatment, the sufferer didn't appear any skin reaction, the whole body have no unwell, the outside week blood analyzes normally.But 3 sufferers who participate for the first time a clinical treatment to study are after cure two months, the tumor has already completely disappeared.In March, 2007, medium modern physics in the section hospital carried on for the third time a heavy clinical trial of the ion beam treatment, carried on a treatment to the third 14 total sufferers.The research personnel projects light upon successful foundation in the last time boundary on, accumulated a larger tumor sufferer to carry on boundary irradiation(2~9s be wild) to the focus noodles, 14 sufferers 46 total irradiationses be wild, further extension can cure the scope of tumor.Also increased a single time a treatment quantity( total quantity constant) in the meantime, treatment time shortenned a sufferer.The curative effect observation cured this time under way medium.

According to understanding, Germany and the heavy ion beam of Japan's being anti-cancer to equip have already carried out industry to turn currently.Cures the heavy ion beam anti-cancer appropriation of more than 1000 sufferers to equip offer to be up to 100,000,000 euros(about renminbis 1,000,000,000) for each year.Medium modern physics in the section hospital accept to set up of national important HIRFL-CSR of the science engineering has already can accelerate carbon ion to attain single nuclear energy 7,000,000,000,000 electronics Fu~1,000,000,000,000,000 electronics Fu and tie regiment carbon ion a number each time big in 1.5 × 109-2 the ×s be 109, basic can satisfy heavy ion beam whole body(any part inside the body) anti-cancer single nuclear energy need about 80,000,000,000,000 electronics Fu-430,000,000,000,000 the electronics Fus count about 108 requests with each bunch regiment carbon ion.The our country has already had to carry on a deep department the clinical trial of the tumor treatment and carry out heavy ion to tie anti-cancer appropriation to pack to buy property the condition for turn, this not only can promote the large medical treatment equipments be creatively independent to cross over a development, and will make the sufferer's treatment expenses greatly in order to reduce, make the heavy ion beam put to treat to bring benefit to further society.