The liver cancer is one of three greatest cancers in the world, more regularly is reside in cancer cause of death of first.Investigate its reason, mainly is because of only about 10 － 20% sufferers of liver cancer can have an operation excision after be taken bad, but most patients have already belonged to a later period while diagnose.Unfortunate of BE, still keep lacking a valid treatment the medicine of the liver cancer currently.This text compromises the cultural heritage that know already currently to introduce to this topic.
The chemistry cure
The curative effect of chemistry treatment to liver cancer is basically disappointing, fresh have medicine to attain 20% reaction rates, also having no a kind of medicine can show extension liver cancer in the random cent set experiment of the patient survive the ability of period.Main reason is because the cell of liver cancer highly the performance has another a heavy medicine drug-resistant gene(mdr), but produce a drug-resistant to most chemistry medicine.Mostly merge because of the patient of liver cancer on the other hand cirrhosis, make the liver metabolize the ability of medicine to become bad, increase the difficulty of treatment more.
"Small red Mei" thought currently that using to cure the most valid chemicals of liver cancer initiates anthracycline medicine, then is so called.Among them most again the doxorubicin be the most in common use.Earlier period the second mutually the clinical trial once reported 100% disease reaction rate of Gao Dao4's 25 －s, but in recent years of the research then onlies have don't arrive 20% disease reaction rate.In the third mutually random cent set experiment, the disease reaction once thering is report to point out to cure liver cancer with the doxorubicin rate better than took 5 － fluorouracil(5 － FUs)s as main chemistry prescription and etoposide, but the survival expected to prolong.Also there is research counteracting Tamoxifen to try an improvement cancer cell to the doxorubicin drug-resistant, but cure a result combine all together.The Doxorubicin once was use as well to cured liver cancer with other chemistry medicine suitable for use, but cure the result and also improve.
Other anthracycline medicine, such as the epirubicin, daunorubicin, idarubicin, mitoxantrone, and wrap the doxorubicin(the doxorubicin of the liposomal － ) of Fu by tiny fat body, all once was used for cure of liver cancer.Once having research paper epirubicin and etoposide suitable for use can reach to 39% disease reaction a rate.But that research expeled many patients with poor liver functions, and the marrow toxicity of this prescription be very big.And the treatment effect of other anthracycline medicine to liver cancer also have no place of show the Zhao.
5 － FUs and it is related the medicine be the most in common use the treatment of the tumor is at the stomach and intestines way.The reaction rate which uses a single time 5 － FU treatment liver cancer for injects alone is about 10 the －s be 28%s.But merge other medicine have no to too greatly help.However in treatment experience of other cancers, the continuous vein drop notes 5 to inject to have better curative effect.But the continuous vein drop note not quite convenience.But all imply 5 － FUs of very high quantity metabolism Mao because of the cell of the normal liver and the liver cancer, dihydropyrimidine dehydrogenase(DPD), so someone try the merger DPD depressant of 5 － FUs that the usage take orally and attain with the period similar continuous vein drop note 5-FU of effect.In a small scaledly the second mutually random cent set experiment, the usage takes orally tegafur(5 － FU forerunner medicine) and the patient of the － DPD depressant uracil to more and only accept the patient of support treatment to have better curative effect.(the reaction rate be 18%, average the survival expect 12 months compare 6 months, p<0.01)But in other seconds mutually of the research, the usage takes orally 5 － FUs or tegafur to merge the eniluracil of the DPD depressant or uracil(UFT) to have no to make a person a surprised and pleased result too much.
Capecitabine, another 5 － FUs develop medicine and have already been confirm to have equal curative effect in breast cancer and the large intestine cancer.But use capecitabine alone is about 13% at the disease reaction rate of liver cancer treatment.And if also there is research report pointing out that the thalidomide of the capecitabine merger useds for the treatment of liver cancer and can have, the rate is about 20% disease reaction.So capecitabine in the future in response to annexable and other clinical trials that the medicine used for liver cancer.
In the small scaled research of a single recent hospital, 5 － FUs which use low doses in a row quiet note cisplatin of merge the low doses can have 47% disease reaction a rate to curing liver cancer, and 7 months of have no disease depravation period.But this prescription need the third mutually a clinical trial in to confirm its curative effect.
Although the yew Chun medicine the detection can repress the cell of liver cancer in the laboratory the research, but on the clinical usage without the curative effect.The Etoposide uses to have 10% disease reaction a rate around alone, but once has a report to point out that etoposide and tamoxifen suitable for use had 24% disease reaction a rate.But this result need the third mutually the confirmation of clinical trial.Gemicitabine single medicine usage's treatment in the liver cancer once had already reported to be up to 18% disease reaction a rate, but can'ted get a confirmation in the follow-up research.But merger Gemcitabine and doxorubicin compared to use doxorubicin to have better curative effect alone, but merge Gemcitabine and cisplatin have already reported to 21% disease reaction of 17 －s a rate, seem to is a worthy of try of combination.The Topotecan, irinotecan and oxaliplatin have no obvious curative effect to the liver cancer.The depressant raltitrexed of the Thymidylate synthase and nolatrexed are poor to the reaction rate of liver cancer treatment, but accept nolatrexed the patient of the treatment seem to be to more accept doxorubicin of the patient have better survival period.There has been currently an in progressly the third mutually the clinical trial is compare nolatrexed and doxorubicin of to the curative effect of the liver cancer.
The hormone cure
The Somatostatin is a kind of hormone, once was reported the Diao Wu that can cause cancer cell and repressed a cancer cell growth, and repressed blood vessel freshman.But have around 40% the cell of liver cancer has somatostain of be subjected to a body.Therefore use somatosatin or its derivatives to cure liver cancer is the choice of one reasonable.In a third mutually of the research, the Kouroumalis waits for someone the sufferer of the treatment liver cancer of the Octreotide(a kind of somatostain derivatives) of the report usage, more and only accept the person of support rapy to have better survival period(13 months compare up 4 months), and better quality of life.And after same research team usage long somatostatin's treatment in liver cancer of effect type, also get a similar result.But other researchers make use of a similar medicine treatment liver cancer, but can't get a same result.After of three researches show, usage long effect type of somatostatin treatment liver cancer, the disease reaction rate doesn't arrive 5%, average the survival expect only 4 the －s be 9 months.Therefore have no proof to show currently somatostain and its derivatives have curative effect to the liver cancer.
The liver cell implies a be subjected to of estrogen body, and the cell of liver cancer of part also is this kind to be subjected to a body.Therefore use tamoxifen, the treatment liver cancer of a kind of estrogen depressant, seem to is a reasonable choice.But the Nowak wait for someone to look back 10 relevant tamoxifen treatment liver cancer recently of large random divide set experiment, do not discover to contain any curative effect by tamoxifen treatment liver cancer.Whereas, there is performance estrogen in 45 cancer cells being win by the patient of liver cancer of body, accept the patient of Huang2 Ti3 Su4's treatment compare the patient who accept support treatment have a longer survival period.(18 months compare 7 months, p=0.009)Huang2 Ti3 Su4 cures ameliorable cancer to also cause of bad physical endowment.Currently cure liver cancer by Huang2 Ti3 Su4 the third under way mutually clinical trial.
The cell which also has a report manifestation the liver cancer has a performance male hormone to be subjected to a body, and the laboratory research show to can repress the cell of liver cancer by the anti- male hormone treatment.The clinical trial once uses the － releasing of the leuteinizing hormone hormone to be in conjunction with medicines such as, flutamide and cyproterone acetate etc. to cure liver cancer, but all without the curative effect.
The immunity cure
The interferon(Interferon) is particularly an Interferon －α , have already been used for a cure of B type and C type hepatitis extensively.The Interferon －α once was used for cure of liver cancer as well.In the － 75 patients' random cent set experiment, the sufferer who accepts Interferon － the liver cancer of α treatment more accepts the toxicity that the doxorubicin patient has better rate and less of the disease reaction.Another one research comparison are inject with Interferon －α and supports sex rapy, discover Interferon － the α injects and can have 31% disease reaction a rate, and better of survival expect.But, the follow-up research all can't confirm the curative effect of interferon.However, in two small scaled researches, to with have operation to cut off tumor after of the sufferer of liver cancer give interferon treatment, apparently can reduce the opportunity for relapse.However this confirmation which needs a large research.
Interferon and chemotherapy suitable for use also haven't a few reports, but mostly mixed result.A small scaled third mutually studies comparison Interferon －α plus the result that the cisplatin cures with support rapy at the patient of liver cancer, the disease reaction rate is only 13%, but survives a period to obviously increase.The merger methotrexat of another a research, 5 － FUs, cisplatine and Interferon －α treatment liver cancer, have already been up to 45% disease reaction a rate.These researches all need a large-scale clinical trial confirmation.
Other immunotherapies include the bad cause of death son of the dendrite form cell, tumor which is activate with cancer cell and have the tumor with single mind and sexually poisons to death T cell, and the subcutaneous injection lie the white quality pluses melantonin on the second.But these ways still test a stage, still have no complete clinical studies report.
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