The mark Ba of breast cancer cure

Because of the progress of medical science, the treatment effect of breast cancer has already included substantial progress in recent years, for transfer the treatment effect of sex breast cancer but speech, the hormone treatment of the usage forefront can attain 30 the －s be 50% reaction rates, but forefront chemistry the treatment then can attain 50 the －s be 70% reaction rates.Nevertheless, but by all accounts, the prepare of patient who transfers sex breast cancer after ising still poor, some the medicine use by treatment, still exist most patients don't take pleasure in accept and face of side effect!



The medicine that the traditional breast cancer treatment use is like CMF, FAC(FEC), AC, TxC, Pac etc., although is cure the curative effect of breast cancer quite good, and ameliorable combine the extension patient's existence period, this kind and anti-cancer poison to death the treatment method of medicine, in addition to killing harm to the cancer cell formation, will also bring injury to normal cell, after cause treatment the creation of medicine related side effect.Aim at the weakness of this aspect, currently the popular anti-cancer treatment way is to aim at inside cancer cell of especially the different member make to stop to result in the message in the cancer cell cell that growth involve when split up conduct of interruption, cause the death of cancer cell, attain treatment reaction of increase the patient a rate and hope to lower treatment the target of side effect cause.



The research know and transfer the second mankind the growth factor of the top skin cell of the cell performance of sex breast cancer to accept the ratio of machine(HER-2) to 20 －s is 25%s, experience of the clinical treatment also discover that the patient of breast cancer of excesssive performance genes HER-2s accepts curative effect in chemotherapy compare without the patient of excessiveness HER-2 expressional breast cancer poor, so if can be to the excesssive performance of HER-2 carry on stop, repress the growth abruption of the cell of breast cancer, will contribute to the growth which controls breast cancer.Currently the mark Ba of breast cancer treatment, have 3 types:Include single stub antibody, small member material and the development of vaccine.If depend on mark Ba the classification of the treatment, classable then stop antibody for the dimerization depressant, anti- HER, the anti--ligand stops antibody, and tyrosine kinase depressant etc..As for, currently still in the development of have already used ligand or antibody as to carry to have system, or poison to death the ligand-toxin of cancer cell with the toxin, and the antibody-toxin compound etc. system.Generally speaking, the medicine molecular weight use by this kind of mark Ba treatment carries tyrosin kinase, the depressant about carries 400 Er, but the molecular weight of single stub antibody then about 150,000 Er.Following depend on breast cancer a mark Ba a treatment the way of possible usage, make a synopsis introduction.



A, single stub antibody:



The single stub antibody has particularity Gao and the toxicity low characteristic, in addition to directly poisonning to death cancer cell, still have the function that the immunity activate, but the weakness be that the molecular weight is too big, can't effectively seep through cancer cell, and have diverse sex because of the cancer cell antigen performance, normal of the cell will also have part of performances, so also can't attain the curative effect of very high ratio.Have already appear on market to there is Herceptin, Exbitax, ABX-EGF, EMD7200, Omnitarg etc. with just in the single stub antibody in the development currently.Single medicine of the Herceptin is been have by usage the patient's forefront treatment that the HER-2 excesssive performance transfers sex breast cancer, or the chemotherapy be invalid after of the treatment have obvious curative effect and merge to patient Herceptin of masculine genders HER-2s the chemistry treatment then has already added a result fruit.With the Herceptin merge European yew Chun(docetaxel) at the patient's treatment reaction rate of the transfer of masculine genders HER-2ses sex breast cancer for 67%;Some other similar of research report, also point out that the Herceptin merge an other chemotherapy medicine also has look alike effect.As for merge other single stub antibodies and hormone product, and merge other living creature products, such as the GM-CSF, VEGF antibody, EGFR depressant and chemotherapy etc., also just in warmly the research.Just, the clinical top should use how long for Herceptin, and relapse to succeed a continuous usage in the cancer disease currently, whether still effectively wait a problem haven't then managed pure.Because, this medicine is expensive, and the curative effect isn't a hundred per cent, so how sieve may the valid patient accept this type of treatment of drugs, is the patient who uses this kind of single stub antibody as breast cancer mark Ba treatment of one important topic!



Two, small molecular weight material:



This type of the small molecular weight material which have something to do with cancer cure can repress combine of the kinase and ATP of the protein tyrosine and study to point out cancer cell if excesssive performance this kind accepts the words of machine and represent a prepare of patient poor behind, the patient's existence period is shorter.Have already hope currently becoming the small molecular weight material which cures breast cancer has the kinase depressant of the HER tyrosine and include a moxa Rui a kind of insect, too west Fo(Tarceva) etc., all belong to accept a machine up the skin cell growth factor of can go against sex depressant;As for other material, such as the EKB-569, CI-1033, Lapatinib etc., then have to accept a machine to the EGFR and the HER-2 of dual repress a function, in addition to Lapatinib, all belonging to can't go against sexual depressant in three types of materials.The function machine of this kind of medicine turns mainly is make use of and accept a machine up of"the ATP － combine part" combine, can't cause to have something to do with cell grow the message conduction activate, but influence grow of cell.Currently, this kind of small member material for transfer the patient's treatment usage of sex breast cancer to report, general curative effect reaction the rate be not high, with moxa Rui a kind of insect for example, it the clinical performance(include part to alleviate and stability disease) only have 12 the －s be 13%s.As for another the medicine which repress in the EGFR and the HER-2 to accept a machine is like Lapatinib, is test indoor have already been confirm to can repress the growth of the cell of breast cancer, may have the curative effect of latent, study to also discover this medicine can be use in some patients who have already produced a drug-resistant to the Herceptin, can also have something to do with chemotherapy medicine merging to use, but this kind of medicine really settles curative effect and and other medicine each other of difference, then need a further study.



Three, the vaccine of the cell of breast cancer cure:



The vaccine treatment of cancer included passive and active immunity to cure 2 types.The purpose that the passive immunity cure is the immune system which uses an outside and source cell vegetable, antibody, immunity cell to increase or stimulate a patient.But active immunity, then use the cancer cell related particularity antigen, cause source immunity inside the patient or anti- tumor to respond.Because of the treatment target of cancer vaccine is the particularity antigen which aims at tumor cell Be mark Ba, hope to increase the patient's immunity reaction, attain a purpose of exterminate the cancer cell.Generally speaking, treatment and traditional medicine of the cancer vaccine compare and have more not poisonous and can merge with the traditional chemotherapy or other immunity treatments the advantage of usage.Clinical currently up there is several type resisting HER to belong to protein vaccine being in imposing arraily carrying on a research, such as the peptide EF5 merge GMCSF usage in transfer a sex breast cancer or ovary cancer patient, result detection originally type the vaccine use at the patient's side effect less, and have inducement patient to produce peptide with single mind sex and epitope with single mind and sexually poison to death the effect of a T cell, can will excessively express the cancer cell deliquescence of HER-2 to kill to put out.But often can't obviously express to have with single mind sexual cancer cell antigen very much because of the patient of breast cancer;Or exist at the cell in the human body plain environment, can't allow a help type the enlargement growth of the T cell;Or the antigen present cell(APC) of can't effectively produce result;And the tumor cell can secrete immunity to repress factor etc. of factor, make breast cancer cure the development of sex vaccine, still have it to limit sex.Currently the usage object of this kind of treatment vaccine, probably also only limit on some patient's treatment of the earlier period cancers, the cancer vaccine still has a farsighted journey to walk for usage but speech that the patient of breast cancer cure.



Conclusion:



For transfer the patient of sex breast cancer but speech, some member structure thing of cancer cell is all probably used to Be the object which marks a Ba treatment.Be that as it may, the Herceptin is still unique have already been admit currently, conduct and actions transfers the single stub antibody that the patient whom sex has expressional breast cancer of the excessiveness HER-2 cure;Other just in the single stub antibody in the development, or small molecular weight protein depressant etc., although may have the effect that the cell of repress breast cancer grow, want Be the medicine of the clinical usage, still need further clinical trial after confirm then can the beautiful dream become really!The applied aspect cured to the cancer vaccine in breast cancer, see by current research, then only may for the cancer disease in earlier period valid, but it accurate curative effect and possibility of apply object and cure the etc. is after the way for track and still needing to carry on a large-scale clinical trial a research rear can make sure.As for, how should aptly merge to use some small member materials, Be the mark Ba of breast cancer treatment use, and it may effectively use object etc., then can make sure after then even needing to progressively study.