The Department of Health (DOH) announced recently the ten greatest cause of deaths lately statisticsed, the cancer still resided a first, and the death rate of breast cancer more and year by year increased.Statistics a manifestation, breast cancer is in all cancers, the death rate gathers speed to occupy the second, only next to mouth cavity cancer, in addition to strengthenning a screen, how is cure a way to look for breakthrough, is the urgent matter of the moment of death rate which lowers breast cancer.
The molecular biology research advances by leaps and bounds in recent years, the special antigen, special growth factor of relevant tumor are deliver by the afferent and new-born and related factor of the body, tumor, the cancer cell special message each kind of member in the path, and cell period inside the cancer cell and cell Diao Wu it adjust and control member, all have a thorough study.The new generation anti-cancer medicine can directly the function then represses a tumor survival, propagates at the above-mentioned target(Target), the part infringe upon and transfer of long range.
Currently many medicines with new breast cancer, be aim at mark Ba(Target), like navigate missile direct hit tumor, avert from normal cell, such will not increase toxicity or side effect, this be also the concept of "mark Ba treatment(target therapy)" of cancer.
The breast cancer mark Ba treatment makes use of a kind of main composition as the single stub antibody of trastuzumab, resist the antigen that the growth factor of the cell surface of Be located on breast cancer is named Her-2/neu(brief name HER2).The sufferer in breast cancer, ignore at domestic and international, about 25-30% patients will be discovered that the HER-2 excessively expresses.
Show in clinical annual convention and large clinical trial in North America of the tumor academic association in the United States, merger chemotherapy and trastuzumab use at the HER-2 excessively express of transfer the patient of sex breast cancer, can promote the reaction rate of chemistry treatment to 50%, also longer reaction period and livability.
The sufferer of expressional breast cancer of the excessiveness HER-2, trastuzumab is also suggest by some scholars to use to lend support to sex chemotherapy after the Shu before or Shu, lend support to sex chemistry under medical treatment after Shu, use the trastuzumab can lower to 50%ly relapse a rate.This kind of single stub antibody is to mark a Ba treatment the first type medicine.
Moreover, cancer cell the epidermis growth factor of the surface is subjected to a body and can extend to the part in the cell and mostly all have Lao An sour arouse ← , be cell after being turn by the sour root phosphoric acid of the Lao An on the body, then will activate incitement cell to grow.Develop a much small member medicine currently, repress Lao An sour arouse ← to attain treatment effect.
The medicine lapatinib of new generation can repress the first, the second epidermis growth factor to be subjected to a body(Her-1 and Her-2) in the meantime, and can cross afferent brain natural cover.Transfer the patient of sex breast cancer to the expressional brain of the excessiveness HER-2, have the first step treatment the result.These small members are to belong to the treatment medicine of the second type mark Ba.
The skin cell growth factor(VEGF) inside the blood vessel is an afferent freshman one of the most important factors.It can urge skin cell inside the blood vessel to survive and continuously split up and result in tumor afferent freshman but help the cancer cell to grow up or transfer.Aim at to repress a blood vessel freshman, currently develop 1 kind call the single stub antibody of the Beva-cizumab, by it repress the afferent freshman of tumor to decelerate a tumor growth, is transfer a sex large intestine cancer have already had curative effect.
Study to discover recently, in many patients who transfer sex breast cancer, the chemotherapy merge Bevacizumab usage, have already had initial curative effect, as for livability then the clinical confirmation of the beard nearer one step.These anti- afferent and new-born medicine then belong to the third type medicine.
In addition to above-mentioned outside, to different signal deliver path, give selectivity to stop or promote cell Diao the mark Ba of the Wu etc. therapy, all in aggressively the development.Compare with traditional chemotherapy like and traditional type bomb, make carpet bomb or scorched-earth policy that the jade accompanies Fen, by all means bring a treatment to win the cancer new chance.
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