Build blood cell transplantation to cure at the lymphoid lump up of applied value

Lymphoid lump at clinical and the classification on the pathology generally can be divided into what hero the gold surname lymphoid lump and not He2 Jie2 Jin's surname lymphoid lump, depend on Department of Health cancer incidence rate in the administration hospital statistics and analysis, not the He2 Jie2 Jin's surname lymphoid lump has the have of case 888 in Year 84 of the Republic of China register, the thick incidence rate has the 11th of cancer occurrence each time for the 100,000 people's 4.18 people, but if study cancer of cause of death then not He2 Jie2 Jin's surname lymphoid lump residents country 87 years the ten greatest cancers die causally the ninth, death rate is each 4.50 people of 100,000 people, as for the ratio of Taiwanese He2 Jie2 Jin's surname in the region lymphoid lump with not the ratio of He2 Jie2 Jin's surname lymphoid lump according to estimate for invite 1-9, compare as far as Euro-American region of 1-3 is low.Because the people lymphoid lump take place of the type be different from Euro-American region, according to report the characteristics that the people lymphoid lump take place includes malignant the T cell type, more knot stanza outside lymphoid lump and less of higher ratio a degree the lymphoid lump of pathologic type and therefore cure generally more Euro-American region lymphoid lump patient of the result is bad!The theoretically lymphoid lump belongs to Medicine chemistry, the treatment can cure of disease, but in fact have many peoples is diagnose the lymphoid lump after treatment still can't get good treatment effect and investigate its reason in addition to paroxysm type especially different outside, treatment up of quantity the strength consideration is still the problem that have to consider!Gao Ji4 Liang2's chemistry cure and build a that the blood cell transplant, the quantity strength has already been super to cause death quantity, it is in the leukemia of the curative effect has already get affirmation, but cure in the lymphoid lump of value with actual how is curative effect?Still the beard inquiries into further and this text depends on to build blood cell transplantation in the He2 Jie2 Jin's surname lymphoid lump and not the treatment of He2 Jie2 Jin's surname lymphoid lump's using situation be introduce as follows respectively.



Build blood cell the transplantation cures to the He2 Jie2 Jin's surname lymphoid lump patient of situation



He2 Jie2 Jin's surname the lymphoid lump patient be traditional ascend with chemistry with a type MOPP, ABVD etc. mixture medicine treatment's can get good treatment effect, but still have parts of patients will relapse or cure after cure invalid, for although this patient(attain 30% around according to the estimate) the second line chemistry treatment or even the third line chemistry treatment, still have 20% treatment effect around, most patients finally can't attain good curative effect, so build blood cell transplantation to this patient, doubtless provided a can cure of opportunity.Took the report of American Nebraska university, medical center as an example to the curative effect which relapsed a lump with lymphoid He2 Jie2 Jin's surname from the body transplantation currently, at some have already experienced many chemotherapies after the He2 Jie2 Jin's surname lymphoid lump patient relapse again transplant, about 57% patients can attain to completely alleviate, it the existence rate for 4 years can attain 45%.But Canadian Vancouver with stronger Gao Ji4 Liang2 and transplanted a treatment from the body then can attain to 80%ly and completely alleviate a rate, thin signed Pu's etc. after 1989 annual reports tell traditional chemotherapy invalid He2 Jie2 Jin's surname lymphoid lump patient accepted Gao Ji4 Liang2's chemistry and projected a treatment and transplanted from the body, 69% patients can attain to completely alleviate, but still have nearly 10% patients because of front the Ge in chest accept project treatment after cause a quality pneumonia but die.So He2 Jie2 Jin's surname the lymphoid lump patient accept to build blood cell to transplant although the curative effect is very good, transplants Gao Ji4 Liang2 stir up chemistry emanation toxicity reaction to is still the problem that have to cogitate!Currently generally accepted He2 Jie2 Jin's surname lymphoid lump patient if want to do to build blood cell to transplant, then have to consider the patient's some factors such as(1) physique appearance(2) previous once accept of chemistry square amount, and(3) whether exist a Ge chamber in chest paroxysm?(4)Whether is the existence more than 10 kilograms lumps?



As for transplant of what is opportune moment?General lay claim to patient if Issue 4, the disease relapse and behind have B symptom or treatment in a year the disease again delivers of patient should for have the initiative the object of enforcement.Because He2 Jie2 Jin's surname the lymphoid lump patient is after transplant of the complications can be up to above 10%, so clinical currently up the target of research is how improve the usage method of Gao Ji4 Liang2's chemistry or project treatment or study other new treatment methods, and many transplantations or for part high and dangerous cluster patient, can consider the usage different body transplant the match build a blood growth the usage of the factor all of etc. is improvement not the He2 Jie2 Jin's surname lymphoid lump patient cure of alternative thinking.John waited to once report different body marrow transplantation to the curative effect which relapses a lump patient with lymphoid He2 Jie2 Jin's surname, after discovering a patient a treatment of relapsed the rate as 18% to far compare to transplant 45% of the patient from the body for low, but different body transplant empress of disease free survival rate then is 47% with from body transplant the patient's 41% match equally, so the different body transplantation needs a further study to this patient's real curative effect!Descend one physically relevant progress which builds blood cell to transplant to cure aspect at the He2 Jie2 Jin's surname lymphoid lump patient, will include various dissimilarity cure the usage, many transplantations of application, single stub antibody of square of implement and different body periphery build blood cell extensive usage etc. of the transplantation!



Not the He2 Jie2 Jin's surname lymphoid lump builds blood cell to transplant



Gao Ji4 Liang2's chemotherapy also builds blood cell to transplant at not the treatment of He2 Jie2 Jin's surname lymphoid lump the later period started to be applied from the 1970's, have already discovered that the patient accepts to cure an empress in 1980's of the curative effect is completely decide in a patient pretreatment disease condition.After the 1990's Gao Ji4 Liang2's chemotherapy also builds blood cell transplantation already in the backlog of the whole whole world a nice bit of case and experience, besides have some random divide the clinical trial report of set come out, currently in the whole whole world relevant various different and high amount of square merger build blood cell transplantation of result, for relapse a type not He2 Jie2 Jin's surname a lymphoid lump patient of 5 year, the livability is about 41%, but the disease free survival rate for 3 years then at 22 － of 40%, far compare with the traditional chemistry cure of disease free survival rate 15% and 2 years, disease free survival rate less than 10% is Gao.As for those hold good to the chemistry treatment of not He2 Jie2 Jin's surname lymphoid lump patient, after transplant of 3 years have no the disease depositor's rate then for 50 the －s be 60%s, so for not He2 Jie2 Jin's surname lymphoid lump patient, accept high amount of to cure and build the blood cell transplants curative effect of decision factor, in addition to patient lymphoid lump organization type, transplant the paroxysm expect do not, and use of cure a square category an outside, the patient is most important before transplantation the disease cure of reaction degree!The patient accepts to transplant ex- chemotherapy reaction, degree not only can influence a patient after transplant of livability, and can even influence a patient Gao Di of the death rate cause by related merger disease is after transplant, such as patient transplant, its disease is chemotherapy drug-resistant, namely its transplantation toxicity respond to 17.8%, but if patient transplant, its disease for after the chemotherapy sensitivity its transplantation the toxicity respond then for 10%.As for transplant the way use for from the body or the different body transplant then still without the hard conclusion.Currently some research papers, transplant the report of group such as the European marrow, point out the transplantation is from the body and different body marrow to ill nature not although the disease free survival rate of He2 Jie2 Jin's surname lymphoid lump all together, at some high and malignant degree such as lymphoid bud ball the lymphoid lump patient transplanted from the body after of the disease relapsed the rate as 48%, but different body transplant after of relapse a rate then only 24%, can know the different body transplantation continuously has marrow invasion to parts of chemotherapy posterities it not He2 Jie2 Jin's surname the lymphoid lump patient and age be younger all can consider for the target which chooses to use!



As for lately build the periphery spread widely blood cell how is the role of the transplantation?European marrow transplants the report of group to point out, the periphery builds blood cell transplantation when patient's disease completely alleviates implement for the first time it to transplant the related death rate as 0%, but has patient's transplantation of drug-resistant in some chemotherapies, related death rate is 7.4%, ratio from body transplant the patient's 17.8% is low, but relapsed a rate to compare to transplant from the body for 0% of 9.8% is low, apparently pointed out that the periphery built blood cell to transplant ignore in the aspects of transplant after of complications and paroxysm control rate all compare traditionally from body marrow transplant good.



Build to the low and malignant degree lymphoid lump what is the role that the blood cell transplant?Traditional top for some thirds and the fourth period although the patient can attain to completely alleviate by the chemotherapy of standard,it alleviate of middle term only have 1 － 3 years, therefore this patient's treatment after the disease free survival rate for 5 years only is 25%!The high amount of cure and build blood cell to transplant at in etc. and the high and malignant degree lymphoid lump patient transplant the result of treatment good, whether can apply a low and malignant degree lymphoid lump patient's body?Point out by the report of American Boston and British London, the low bad habit more difficult degree lymphoid lump patient transplants behind of related erupt the death rate as 10%, the disease free survival rate for 5 years for 50 － 60% see, seem to be Gao Ji4 Liang2's chemotherapy and build blood cell transplantation to this patient of the treatment have good prospect!Because low and malignant degree the lymphoid lump patient is medullary while transplant of the invasion rate be up to 47 the －s be 61%s, so carry on transplanting from the body should still in consideration of lymphoid lump cell inside the marrow cleans the possibility of procedure enforcement!



Conclusion



Build the blood cell transplant of promote is the application which comes from a chemotherapy quantity strength idea at the lymphoid lump patient, currently although still made sure of random cent set report to definitely point out to build blood cell, the transplantation really slices sex, general the malignant degree or the high ill nature in the approval not He2 Jie2 Jin's surname lymphoid lump patient if disease again relapse but its disease is chemotherapy sensitivity appearance, can consider giving transplantation, once patient disease condition for drug-resistant usually prepare poor gave an arrangement transplantation and be not as well effective at this time behind.As for patient if have to prepare the factor poor disease behind whether can while completely alleviating for the first time namely accept transplantation to then have a controversy, the adult lymphoid lump if high and malignant degree can consider immediately accept transplantation while completely alleviating for the first time, but some so-called currently adjust amount of's strategy of the treatment with the dangerous factor then is extensively adopted by the whole world, so some respond to forefronts chemotherapy poor or only attain the patient whom the part alleviate in response to is consider that accepting transplantation cure of apply object.As for periphery build blood cell to transplant in order to having quicker marrow to recover speed, so have already extensively replaced to transplant from the body marrow currently, but deny periphery to build blood cell the curative effect of the transplantation compare marrow the transplantation then still have a controversy so!But different body periphery build blood cell transplantation because of involve the donator long-term safety and transplantation chronic transplant the body resist the complications problem of the host paroxysm, whether after transplant patient true ability because of transplant the body resist lymphoid lump cell a function but have longer transplantation young man to save period and better quality of life, treat further research reason pure!