The tumor that the malignant and lymphoid lump develops for the lymphoid system, is divided into what hero gold surname and not the He2 Jie2 Jin's surname lymphoid lump be 2 types and belong to the latter in native area near 90%.Not the He2 Jie2 Jin's surname lymphoid lump can is divided into B and T cell according to its immunity characteristic, the region's the former has around seven arrive 80%;But depend on its malignant degree or encroach upon sex can is divided into three major types: low, medium and high and malignant degree, clinical top about four arrive 50% not He2 Jie2 Jin's surname lymphoid lump for medium sex large B cell lymphoid lump of the fill the air of malignant degree(encroach upon sex).Not He2 Jie2 Jin's surname lymphoid lump if haven't yet a treatment, the high and malignant degree patient may only survive few day to few week, but medium malignant degree then only several thoughtful several months.Very lucky of, the lymphoid lump is to the chemistry medicine, project a treatment, even very good at the curative effect of the anti- tumor antigen single stub antibody of recently usage, a part of patients even can recover from illness.
Project the line treatment was use to cure lymphoid lump at the earliest stage at the beginning of 20 centuries, however only canned aim at to limit a part treatment because of it, only used for minority's only limitting the sufferer of the part lymphoid lump in the early years currently, or use to Be a whole body chemistry treatment the part strengthen a treatment after it.To mostly lymphoid lump sufferer, the chemistry treatment is still it main treatment method.Initial stage from 20 centuries the development beginning of the chemistry medicine, discover much medicine,such as hydrocarbon, turn a type of etc. to have very great curative effect to the lymphoid lump, but this helped realize a 7 O an age since start develop a merger usage the hybrid prescription of various valid medicine a treatment a method, so 8 O age appeared various well-known and lymphoid lump a mixture prescription like CHOP, mBACOD etc. forefront treatment prescription, because still have one the part of patient cure ineffective or relapse, book from merger other haven't used of medicine, aggravate amount of or change to inject a way, go to a 9 O the beginning of age in the end of age of 8 O, spread out so-calledly and the second line a treatment prescription is like DHAP, ESHAP, EPOCH, ICE etc..Expect a marrow(build blood a stem cell) transplantation's technique at this time gradual mature, the clinical doctor is very quick of makes use of it to cure a lymphoid lump patient.
The marrow(build blood a stem cell) transplant depend on move vegetative source can is divided into be two major types from the body and different body, from body transplant of premise have to the tumor had good curative effect to the chemotherapy, book from transplant ex- higher amount of treatment, kill more cancer cells, however because this will result in in the meantime marrow or built blood system can't recover, so had to lose to note to store in times before of built a blood stem cell to save and recover to build blood system from the body, the lymphoid lump adopts this transplantation more currently;But the different body transplant, because of oneself it the complications be more and cure at the lymphoid lump currently up is make use of in high and malignant degree, marrow more the sufferer who has infringe upon or resists stubbornly a lymphoid lump.From body marrow and build a blood stem cell, the transplantation begins from a 8 O the end of age in the treatment of lymphoid lump, but 9 O age initial stage already from large third mutually of clinical trial confirm that it can prolong to effectively relapse the survival period of lymphoid lump sufferer to the chemotherapy, this has already make use of in Taiwan in clinical up.However whether that treatment can be use in "Be already alleviated by forefront chemotherapy, but have Gao the patient who relapses a risk" in advance or not, many clinical trials started aim at this problem to carry on a research age middle from the 9 O, however housebound choice and the dissimilarity of the prescription of the forefront chemotherapy for suffering from dangerous factor, each research conclusion combine inconformity, luckily announced to after new England medical science the third mutually large clinical trial of the periodical, its forefront treatment use CHOP, discovering these belong to win and Gao relapsing a dangerous cluster of patients, in forefront chemotherapy attaining to alleviate and immediately implement to transplant from the body recently, can prolong a survival period, currently so of the idea also is quote from in a Taiwanese medical center.In addition, well worth mentioning is along with transplant a caring technical progress, have already can promote from the age limit of body stem-cell transplantation currently 65-70 years old of.
In addition to before speaking of chemistry medicine and building the progress of the blood stem-cell transplantation, the lymphoid lump cure of the progress also does obeisance the progress of foundation immunology, along with the 7 Os and the 8 O is to understanding of the immunity cell(T cell and B cell) performance antigen age initial stage and in addition to being make use of in the classification of lymphoid lump first, the scientist also tries the single stub antibody that the exploitation aims at these antigens to cure lymphoid lump.However early this treatment's being have another by source of be limited by the antibody be produce by the animal, inject the human body will produce bad immunity reaction, in recent years because of the progress of genetic engineering, book from change the structure of single stub antibody to make it a "humanization", have already started use currently in clinical up, bloom and bear fruit among them of would be anti- CD the single stub antibody of 20 antigens.
CD20 antigens evolving process in the B cell will have a long-playing performance, so most of the B cell lymphoid malignant tumor, or many or little single stub antibodies which resist CD20 all have curative effect, is particularly so-called and low and malignant degree lymphoid lump, however because of this patient survival period long, not easy judgment this treatment used in early days to survival period of influence, this medicine of real in great quantities use is lie in old age of filled the air sex large B cell a lymphoid lump sufferer, recently through the large research confirmation:Merge chemotherapy and anti- CD 20 antigens single stub antibody to cure, can increase curative effect and prolong this patient's survival period, this right and wrong He2 Jie2 Jin's surname lymphoid lump treatment history of important milestone.Because this patient is pure to accept a traditional chemistry treatment, the toxicity is big and easily relapse, and don't easily implement higher amount of treatment, usually prepare poor behind.In addition this medicine also changed to just understand gradually for another decades of mantle cell the treatment of the lymphoid lump patient and after prepare, this lymphoid lump is take place in an age bigger patient, easiest have marrow invasion and use a chemotherapy alone before, the toxicity is big and the curative effect differ.The recently research discovers merger the treatment of this single stub antibody, can improve curative effect, if in the meantime use it after from the body before building a blood stem cell collections and transplant and not only can turn down disease to relapse a rate, but also can prolong the patient's survival period, is one big evangel to this patient.
From above we can understand, from discover single chemotherapy medicine to merge to the treatment of lymphoid lump the hybrid chemotherapy prescription of several valid medicine;From the usage forefront hybrid the chemotherapy prescription arrive to develop higher treatment and stem-cell transplantation for measure;And understand a clinical classification of improve the lymphoid lump and develop a single stub antibody clinical usage from the research of immunity cell antigen, the treatment of lymphoid lump walks on each cancer to cure forever of head.The book is can be cure by these lymphoid lumps which cure, have already had more sufferers and the sufferers who hope this text to diagnose lymphoid lump to the beginning have a help, never give up a regular treatment.
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