The lymphoid lump categorize and its importance

At the sickroom a side of the hallway, usually can see the family members circumambience of anxiety is by the side of the doctor in charge's body, they are eager to wanting to know, "what is a lymphoid lump?", " The lymphoid lump prepares behind how?""Why separate a bed the sufferer cure of is the policy with our dissimilarities?""Similarly lymphoid lump, why have of person's symptom be more easy but does someone feel very seriously?"Yes, these problem not only perplex sufferer and its family members, also in the meantime how much exist in the heart of many junior resident doctor perhaps other section doctorses.



Look back of history



The above-mentioned problem basically relates to classification and its importance to the clinical treatment of lymphoid lump.Answer question before, we have to do one historic review in the last few decades to the classification of lymphoid lump.With generally last skin cell the tumor be different BE, the categorize of lymphoid lump is from 1966 Rapapport beginning, then cause a tremendous controversy, main reason's lying in at that time this to all and slightly divide a method really can't suit cell metamorphosis, doctor can't from classification of assign name to drive up prepare behind or the related clinical meaning of the cell biology, use of name,such as"organization the spheroid lymphoid lump", can't as well real reflect lymphoid cell to change for the lymphoid lump of corpus.



In the end of 60's, the observation learned through the appearance, the first step understands lymphoid cell after being stimulate by antigen, is living the hair center metamorphosis of each stage, although only be limited by the B cell change of type, but is an important one step.Dye because of immunity chemistry 70's technical of make progress and fusion the lump technical progress, the emergence of various single stub antibody makes to cure boundary to explain a T and B cell gradually to evolve a type furtherly.Because of these neck, help realize in the early part of 80's the lymphoid lump classification gets in to let a hundred schools of thought contend of ages, this at that time expects have in the United States the national cancer institute for research put forward of Working Formulation, there are the method, another Luks and Collin of the Kiel classification in Europe put forward more more the forerunner's function classification method, unfortunate, these classification because each other stands on the different understanding foundation, the reason of the basis idea, and whole to lymphoid cell the understanding be not enough, perhaps because the laboratory technical difficulty, the different clinical doctor, pathologic doctor used different classification word at that time, each result which sang to eachly adjust, usually result in communication up of difficulty and research the work can't carry on, and the classification also sank into fog very and very of scene, the just so-called mentally dense openned, first light of day early Lou.In the end of 80's, because of the molecular biology and the further development of the immunity chemistry, cure boundary to evolve the T cell and the B cell to there is more complete and thorough understanding.But the lately lymphoid lump be like the coat cell lymphoid lump, the edge area cell lymphoid lump, the nose T/NK cell lymphoid lump etc., is confirm further from the old classification, so make unify of word and lately categorize an appear of method it a necessity.The classification of the T cell lymphoid lump in 1987, is put forward first, the Kiel of immediately after new version categorizes a method to appear, until 1994, Europe and America and several experts with pathologic bloods in the world take the Kiel and the Working Formulation as foundation and put forward REAL(the Revised European-American Lymphoma Classification)the classification method and further WHO classification is wide to is accept by everyone after.



The foundation of REAL/WHO classification



The REAL classification integrates lymphoid cell in the latest knowledges, such as appearance, immunity, virus, cell heredity and molecular biology...etc., but classifies lymphoid lump the second type of many dissimilarities, each of the different second type have different clinical special features, good hair part, special surface marking, the virus of connection and some and special heredity gene of variety etc..These the knowledge make well-trained tumor section doctor can immediately understanding from the classification patient of the whole condition, then can quickly aim at a sufferer a condition an arrangement appropriate of check and treatment policy, and judge possibility of prepare behind.



Classified importance



(A)Provide the important message that the sufferer prepares behind



Compare the difference of course of illness and five years livability, the malignant and lymphoid lump can classified into next say a different type:



1.the Gao encroach upon sex malignant and lymphoid lump:The lymphoid lump which belongs to this type include:Peripheral T cell lymphoid lump, lymphoid and female cell lymphoid lump, the liver Pi T-r δ cell lymphoid lump, afferent immunity T female cell lymphoid lump etc., the five years livability of this kind of sufferer invite about 30%.



2.encroach upon sex lymphoid lump:The lymphoid lump which belongs to this type include:Fill the air for five years of sex large B cell lymphoid lymphoid large T cell lymphoid lump etc., this kind of sufferer of the lump, degeneration of the lump, Burkitt surname, the livability invite at 30 － 50% be or so.



3.slow-moving type lymphoid lump:The lymphoid lump of this type include:Small lymphoid ball type, filter bubble type, mucosa connection type, the syrup cell type, coat cell type, mushroom form fungi disease, CD 30+ epidermis T cell lymphoid lump etc.s, five years of this kind of sufferer, livability invite at 50 － 70% be or so.



(Two)Can provide the course of illness that the clinical doctor predicts sufferer's possibility



For example He2 Jie2 Jin's surname lymphoid lump sufferer, the part most which is encroach upon is a continuous of, this is entirely different in not the whole body of He2 Jie2 Jin's surname lymphoid lump distribute.



(Three)Provide clinical doctor sufferer a possible to be clinical cent to expect, benefit in with the check check against as a result, in order to in advance arrange treatment policy.



For example when the clinical cent of the great majority mucosa connection edge area B cell lymphoid lump expect for Issue 1 or 2s, many peripheral T cell lymphoid lumps, the coat cell lymphoid lump, fill the air sex B big cell lymphoid lump is Issue 3 or 4s.



(Four)Provide the knowledge that the cause of disease learn



For example adult the T cell lymphoid lump and virus HTLV-1, the relation between the nose T/NK cell lymphoid lump and EB virus is close, these information hereafter perhaps contribute to prevention and cure.



(Five)The research development provided a possible heredity message, contributed to will cure in the future.



Have already know various lymphoid lumps have a special relation with some genes, is 1-1 genes such as the lymphoid lump and bc of the coat cell and filter a bubble type lymphoid lump and bc is 1-2 genes, these informations will perhaps contribute to prevention and cure in the future.



(Six)Make to cure boundary to know the imperfection, improve the weakness of treatment



Because the pathologic classification of lymphoid lump, we can know to cure currently of imperfection, put forward improving a project to help a patient.



Correct treatment idea



With generally last the skin cell cancer dissimilarity, the lymphoid lump is a kind of cancer that can cure.Many factors have to think it over before cure and categorize is among them important of one wreath, other include age, sex, healthy condition, personal will, family factor economic condition even, thus whole match, then can acquire the best curative effect.