Project the treatment is the basic treatment means that the nose swallows a cancer, can obtain a higher partial control rate, but because of its growth quick and Gao transfer characteristic, make that disease exist higher treatment failure rate.Therefore, for further exaltation the nose swallow cancerous treatment level, people have been including a chemistry treatment in the research at inside of comprehensive treatment means.The chemistry treatment useds for a nose to swallow a cancer to have 30 years around, already from single medicine treatment at most the medicine consociation cure.Cure the way has an appeasement chemotherapy, lend support to a chemotherapy, induce a chemotherapy and put a chemotherapy etc. in the meantime.
In past more than 20 years in, chemotherapy Be 1 kind swallows to the nose cancerous of standard therapy, only be limited by to transfer an appease of cancer a treatment towards relapse or.In the last more than 10 years, the chemotherapy consociation puts to treat to cure the clinical research that the partial later period nose swallows a cancer to carry on in many centers, although the chemotherapy obtained higher and efficient, it to have no disease existence and total the influence of the existence rate still exists a controversy.
Appease sex chemotherapy
Since go toward to think that the nose relapsed and(or) transfered's swallowing a cancer is hard cure, the chemotherapy is these the sufferer's treatment choice.The purpose of chemotherapy is ease have already had symptom and defer new symptom of emergence, making the existence expect can prolong.Therefore be called the appeasement to this kind of chemotherapy chemotherapy.
The nose swallows a cancer to the chemotherapy sensitive, is swallow a cancer to alleviate the rate higher single medicine to have an agreeable platinum(DDP), 5 － fluorine Mao Mi Ding(5 － FUs)s and compare to the nose soft come to mildewed than star(ADM), ammonia A Die purine(MTX), the wreath Lin Mao An(CTX) and Bo vegetable(BLM) etc..A great deal of of clinical trial already confirm many medicine consociation the chemotherapy is better than the one use a medicine.The nose swallows the chemotherapy mode of the cancer appeasement already from single medicine treatment transition at most the medicine unite chemotherapy.Have many different consociation chemotherapy a project to be try out to swallow a cancer at the nose, use now most is to contain a platinum project.The clinical trial has already confirmed that containing a platinum project compare in don't contain a platinum project to have to higherly alleviate a rate.The most use consociation project is a DDP now+5 － FUs.
Although existing appeasement chemotherapy project can obtain higher and efficient, alleviate a period short, the only very few few suffererses can exist over a long period of time, so people still keep aring try a new consociation project or using new medicine currently.
In fine, in past more than 20 years in, to relapse and transfer a nose to swallow cancerous ppeasement a chemotherapy already from single medicine treatment change is the consociation chemotherapy of various medicine.The curative effect is also 30% efficient increase to above 50% from 20% ～s of single medicine.Appease sex chemotherapy effectively often can ease symptom or alleviate the emergence of new symptom and also having a handful of cases can survive over a long period of time.
Induce a chemotherapy
The chemistry treatment which puts to use before treat is called inducement chemotherapy, and then call new assistance chemotherapy.Induce currently the chemotherapy project generally and all adopts to contain a platinum project, like PF(DDP+5 － FUs), PBF(DDP+BLM+5 － FUs)...etc..Generally use 2~3 periods.The control which induces a chemotherapy to swallow the cancer partial symptom to the nose is quickly valid.But currently as to it's the report way of long-term effect be still inconsistent.The research of the earlier period is mostly some not- random clinical trials and and is hard to judge it swallows the value of cancer under medical treatment in the nose.Some prospect random check against a research in recent years and get one more the conclusion that the long-term existence rate didn't show a Zhao improvement.The international nose swallows the prospect for carry on of the cancer research cooperation set to random check against a research manifestation, induced a chemotherapy to raise to have no the existence rate of disease, but to total the existence rate influenced.In fine, induce although the chemotherapy swallowed a cancer to obtain to higherly alleviate a rate to the nose, in the random check against of the great majority the research, this kind of Gao alleviated a rate and don't convert into the advantage of existence rate.
Same period chemotherapy with put to treat
The same period turn, puts to treat to mean that the nose swallows a cancer to use a chemotherapy at the time of projecting a treatment.The DDP is a most often applied medicine currently, the DDP all proves in outside inside the body its special emanation increases a quick function, and its normal regulations amount of to the marrow repress more and lightly, with put to treat a toxicity not mutually layer after layer.
Lend support to a chemotherapy
Lend support to the chemotherapy that the chemotherapy uses after meaning the emanation treatment.The pure research lends support to the cultural heritage less of chemotherapy.Parts of researches hint that the assistance chemotherapy contains existence advantage, but these research for not and random study and go into a set a case too little, hard elucidation problem.
In fine, assistance the function of the chemotherapy is still not clear now.Because the focus concentration noticed currently turn, puts to treat in the same period, so can hardly have an explicit conclusion to the function of assistance chemotherapy in the near future.
Other combination methods of chemotherapy
Other combination methods of chemotherapy contain inducement chemotherapy+assistance chemotherapy, the corresponding period turn, puts to treat+assistance chemotherapy etc..
Carry on at most currently of is the research that the same period turn, puts to treat to add an assistance chemotherapy.A prospect that the American The intergroup Study carry on random checks against a research and turn, put same period to treat to add assistance chemotherapy and simplicity to put to treat to carry on a comparison.Have no progress existence rate for result two sets of 3 years is 69% and 24% respectively, 3 years always the existence rate is 76% and 46% respectively.This is the first usage same period to turn to put to treat to add assistance chemotherapy and simplicity to put to treat to compare, can obviously prolong existence to expect of random check against a clinical trial.This clinical trial displays an obvious improvement existence a period, so ever since that time should experiment to announce, the same period turn, puts to treat(the DDP 100 mgs/m 2, once/3 week, in a row 3 periods) to add assistance chemotherapy(the DDP 80 mgs/m 2, d 1;5 － FU1 g/ms 2, d one ～ d 4, a period every 4 weeks, in a row 3 periods)have become American III, IV to expect the nose swallows cancerous standard a treatment mode.But because of should experiment a report way of pure put to treat a set of existence rate obviously low wait a nose to swallow cancer fad region simplicity to put to treat in Hong Kong of existence rate, chemotherapy set existence rate not obvious good to Hong Kong wait a nose to swallow cancer fad region simplicity to put to treat of existence rate, so this strategy hasn't been used for all crowds of standard cure.Currently, Hong Kong, Singapore and Taiwanese etc. nose swallow a cancer Gao Fa Qu all under way same period to turn, put to treat III of add the assistance chemotherapy to expect to random check against clinical studies.
Prospect
Much chemotherapy medicine has already been prove to swallow a cancer to the nose valid.But actually He2 Yao4 be the best and stay at the further research.In the nose swallow the cancerous consociation chemotherapy the project, contain the platinum project is the main project which makes use of currently, and is think to be the combination project of the valid dint, but medicine with the platinum project combine, quantity and treat a distance to have no a program of standard currently, this also is treat in to large-scalely and random check against an experiment.
Build blood a stem cell to transplant under support of super and big quantity the chemotherapy have become more mature tumor to cure means.The nose swallows cancer as a kind of chemotherapy the tumor of the sensitive, is build a blood stem cell under support, raise a chemotherapy quantity strength, perhaps will raise curative effect further.
Exist a controversy towards inducing a chemotherapy, same period to turn, put to treat with lend support to chemotherapy of evaluate so far return.A kind of each combination ways includes respectively of advantage and weakness.The chemotherapy consociation puts to treat to actually adopt what kind of combination method is one of the a little bit the most hot problems that the nose swallows a cancer research realm in recent years.Ever since American The intergroup study 0099 after announce, that research adoption of the same period turn, put to treat to add assistance chemotherapy to become North America III, IV to expect the nose swallow cancerous of standard treatment mode.But that mode still need in the nose to swallow cancer fad area to go to random check against to experiment to take in to confirm.
The intergroup study 0099 differ from other researches to lie in it at put to treat in and put to treat after all used a chemotherapy.The improvement of existence rate is to receive benefit to turn, put to treat in same period, or receive benefit at the assistance chemotherapy, or two all rise a function and this needs to turn, put to treat or lend support to a chemotherapy to take in to study alone to the same period.If mainly is to receive benefit to turn, put to treat in same period, then plus assistance chemotherapy be a kind of excessiveness treatment.If the improvement of existence rate is really the result that the same period turn, puts to treat to add an assistance chemotherapy to be in conjunction with a function, then have to maintain this kind of mode.
We should further and deeply turn to swallow cancer biology the research of the characteristic to the nose and look for can accurate estimate condition development and index sign after prepare, carry out a fitting individuation treatment to the sufferer of different condition of patient.
Used for a nose to swallow currently although the cancerous chemotherapy medicine obtain higher and efficient, long-term effect still the disregard think, and exist more serious poisonous pair to respond.So have a necessity to look for further efficiently but the medicine of the low poison.The 90's in 20 centuries new medicine Ao sand benefit platinum, Jian chose to obtain certain effect with CPT －'s 11 etc.s in the under medical treatment of parts of tumors.These new medicines swallow to the nose how is cancerous curative effect?Can go a further system research to it.Swallow cancer medicine to cure to the nose of study a further development to lie in the research development of new medicine that the member Ba order.There has been parts of medicine getting into clinical II currently, III period experiment in
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