The child impatient lymphatic leukemia

Taiwanese every year lately diagnoses a patient about 757 child cancer, among them, the leukemia has 40% around the most familiar.The leukemia is because of leukocyte malignant to increase to living with the result that.The characteristics of impatient leukemia is a marrow is occupy by same not mature leukemia cell;And at chronic marrow leukemia, although not mature leukocyte increment, more mature each stage leukocyte is also many.The child leukemia is in the middle, 97% is impatient, chronic of less see.The leukemia cell derives from lymphoid ball to fasten of and be called a lymphatic leukemia;But derive from other leukocytes to fasten of, become a not- lymphoid sex(or marrow) leukemia.Child the impatient leukemia be in the middle and the lymph is many triples than the marrow around.



The impatient lymphatic leukemia is the most familiar in about 4 years old.The sick kid is usually pale(anemic) because of facial expression, the fever doesn't back, bone pain(often the misdiagnosis is for the arthritis), bleed tendency(particularly the calf order form issue of blood), lymphoid swelling of gland big, the liver Pi be greatly swollen, languid, appetite bad etc. be unwell, see a doctor.Doctor through inquire the history, physical examination of disease, but doubt a problem, will draw blood check blood cell.While suffering from the sick kid of impatient lymphatic leukemia, presenting above symptom, all of its marrow cell above 70%s were already leukemia cells, so it normally builds blood function, also therefore and greatly is influence.Blood cell number and leukocyte classification of its blood, as well can't completely normal.For example:The hemoglobin(representative red corpuscle) is low, is anemic;The blood platelets is also low, easy bleed;Leukocyte number of the scope can be very big, can from 500-200,000/sign a square millimeter, but the normal leukocyte generally will reduce and also easily cause an infection.In addition to the leukocyte of a handful of sick kids number little in 2 and 3,000, other patients blood puts on a slice of top to appear leukemia cell in response to the meeting, through the microscope examination, the expert can immediately discover these leukemia cells.The marrow needle absorbs a check very quick but safety, sample a little amount marrow liquid, its check body imply the density very high leukemia cell, can used for the characteristic that the precision authenticates leukemia cell and include appearance to learn, cell marking(immunity form type), chromosome or gene abnormality.These varieties which be limited by leukemia cell will not have in the normal cell;When the leukemia cell has already been exterminate, will not appear in the marrow.Manage the pure leukemia cell have which characteristics, can accurately categorize it, give the treatment of appropriate strength, and can estimate its curative effect.(namely"prepare behind")



The factor is in the middle after prepare and have most decisive be treatment oneself.The most valid treatment can cure the most patients.Under one years of age while diagnose, the most difficult cure, and full 10 years old above of also more difficult.In the meantime, leukocyte number at more than 50,000, as well more difficult cure.At Taiwan, divide with the cell marking, 10% is a T cell, 2% is a B cell, other is a B forerunner cell.Have already known that the B cell impatient lymphatic leukemia can adopt the chemistry treatment of special short date in recent years, the T cell impatient lymphatic leukemia can adopt the treatment for stronger two years, its curative effect is all unlike generally bad.Therefore, cell marking although to decide that curing a way is very important, to prepare behind not so important.The chromosome of the leukemia cell or the some and particular variety of the gene, have of mean to prepare not good behind, some but contrary.The chromosome has no the abnormality of structure, just number(normal is 46) than 50 and the rise of, it prepare very good behind.After starting cure, more leukemia cell's being quick be disappear by the blood or the marrow, it prepare good behind more.More than 20 year agos is divided into 3 types: L1、2、3 by the appearance of leukemia cell.Because of the L1 and L2 the boundary be not that objective, but the L3 almost equals B cell again, the valuation that is after today this kind classification method has already been think not to contribute to prepare.Girl because of to treatment compare sensitive, it prepare behind average compare male a good many.Also compare a trait of to shorten to cure female to two years or two and half years in recent years.



Concerning this disease, the most important idea BE:70% sick kids can cure!According to the treatment in nowadays and then talk, is risen on the whole by the treatment's beginning, seven years after if relapse, be cure.The healing kid can be like ordinary people similar become a house to establish a career to make a living.It isn't a heredity since then, if chromosome or gene of leukemia cell contain abnormality and also be limited by leukemia cell and it can't infect, either.



Western advanced countries factor after studying for several years, having already established the principle of "the cents cure", namely according to prepare, patient's cents, give the treatment of importance moderation, with decrease side effect and linger effect, preserve good treatment result in the meantime.Remove the B cell impatient lymphatic leukemia very specially outside because of its treatment, 98% other sick kids according to it prepare behind the factor can is divided into a standard dangerous cluster, high and dangerous cluster, very high and dangerous cluster.As for the baby of disease under one years of age, the most bad after prepare, the advanced countries tries to give special therapy in recent years, expect to improve its cure rate.At Taiwan, the standard dangerous cluster has 45%, the high and dangerous cluster has 28%, and the very high and dangerous cluster has 27%.(among them the T cell leukemia have 10%, the baby has 2%, other 15%s)



The effect of the treatment, from has been have a progress from 1960's, mainly is because increase the essence understanding of this disease day, chemistry medicine of the progress of the treatment, related medical science of the development(particularly know how match, what amount of the most appropriate), the central nervous system system prevention, include antibiotics, diagnose related science and technology, transfusion medicine, image medical science, nursing to learn, project a treatment, surgery, social service, dietetics, spirit science, rehabilitation medical science ……etc., and international ascend the result of large-scale and clinical research guided whole world treatment of new trend.Currently, advanced countries, the cure rate of this disease is gone to 80% by 55% not to wait.At Taiwan, the cure rate of this disease is already done not arrive 30% to progress to 60% by 30 year agos.



The treatment was five leadings of around weeks to alleviate a treatment in the beginning and took taking orally the adrenal glands skin quality vegetable to plus several medicine for injections as the main force of treatment.Adrenal glands skin quality vegetable is to kill the very valid medicine of the lymphatic leukemia cell, the side effect is that face and torso's aring gradual would be falsely fat, the appetite greatly increases, these side effects gradually will disappear after reducing a medicine and stopping a medicine from five weeks, with growth the disease have no a connection.After five weeks, check marrow, if leukemia cell already several near disappearances, the marrow has been nearly normal, be reach to"alleviate".There is or so 95% in the sick kid being can reach to alleviate by this treatment.Immediately after carry on necessary make stronger a treatment, used for a leading to alleviate a different medicine combination to fight a handful of remenant leukemia cells, alleviate appearance in order to the consolidation.After, again give similar beginning hour guide to alleviate of the medicine make "again guide to alleviate", can even raise a cure rate.The some advanced countries even gives twice"again guide", see whether curative effect will be better or not.The standard cured in recent years, is as early as possible give strong treatment, Be alleviate, made stronger a treatment by leading, again guide to alleviate...etc., at treatment of the initial stage as far as possible exterminates leukemia cell to the minimal quantity.End, get into maintenance therapy(continue therapy), cure have already become easy.Moreover, because of be taken bad meninges how much have already been infringe upon by the leukemia cell, although only don't arrive 10% children can be diagnose by the brain spinal cord liquid to fasten a leukemia for the central nervous system, to all sick kids all the beard give the prevention the treatment, and good more early more.With thin needle through Sui sheath inside inject chemistry medicine, the result is very good.But sometimes return beard after several times injecting to the sick kid of higher and dangerous cluster, and a little amount Lu department project a treatment to complete the treatment of this aspect.This disease sick kid's hasing part will cure failure, mostly is because the leukemia relapse beyond control behind, some is because of severity infection, minority because of other complications, or because leukemia can not in the beginning drive alleviate with the result that.The part of relapse is at most a marrow, secondly fasten for the central nervous system, occasionally it is thus clear that at the testicle;Sometimes relapse part not only 1.Every just relapse after curing to complete of, better after prepare;Relapse no longer than one and half years in the treatment of, specially bad after prepare, if can be alleviate again, should consider accepting different body marrow transplantation.When the beginning diagnose, about 9% sick kids, its leukemia cell has already prepare behind specially bad of chromosome or gene abnormality, if can be alleviate, can also consider marrow transplantation.In addition shouldn't immediately make marrow transplantation.



Treatment originally disease, need to cooperate the professional team of the medical treatment between noons, even need a parent of full understanding and match.One of the team diligent direction, is don't make parent misbelief special prescription, even therefore delay or give up a valid treatment.The parent deserves guide line and mental state of team to support, know a care sick kid, reduce a sick kid to be subjected to the opportunity that the danger violate, medical treatment team and the parent's target are completely consistent, be:Cure a sick kid!