The cause of disease of leukemia

Although through a great deal of research work, the cause of disease hasn't completely understood.Think to relate to following factor currently.

1.Virus factor

The RNA tumor virus is in the animals, such as rat, cat, chicken and cow...etc. of with the result that the leukemia function has been affirmative, this virus with the result that of the leukemia belongs to Ｔ cell more type.The recent years is from the adult T cell the leukemia and lymphoid lump sufferer separate the T cell leukemia virus(HTLV) of a mankind and it is a kind of C type to converse to record virus.Also discover the antibody of the anti- HTLV structure egg white in Japanese's the T cell leukemia patient's serum.But haven't discovered the explicit relation between this kind of virus and child leukemia currently.

2.Chemistry factor

Some chemistry materials have with the result that the function of leukemia.Such as the incidence rate Gao of the crowd leukemia of the contact benzene and its derivatives in general crowd.Second nitric An material, protect Tai loose and it the derivatives, chloromycetin...etc. induct a leukemia of report also it is thus clear that arrive, but still lack to statistics data.The cell poison thing of some anti- tumors is like nitrogen Jie, wreath Lin Mao An, A Ji Xia Pian, VP16, VM26 etc.ses, all generally accepted have with the result that the function of leukemia.

3.Project a factor

There is definite proof affirming various electricity to leave a radiation condition can cause mankind's leukemia.The occurrence of the leukemia is decided by human body absorption the quantity, the whole body or parts of bodies of the radiation to be subjected to measure in etc. or big amount of the radiation can induct a leukemia behind.However, small the radiation for measure can cause a leukemia, still indetermination.After Japan wide island, Nagasaki explodes atomic bomb, the outbreak rate which is subjected to serious leukemia in the radiation region is be not subjected to radiation region of 17-3000%.3 years after explode, the outbreak rate of leukemia year by year increases Gao and attain high peak for 5-7 years.Go to after 21 years its outbreak rate just recovers close at the whole level of Japan.Project a line worker, project line material to usually get in touch with the leukemia outbreak rate to obviously increase.Accepting to project line diagnosis and treatment can cause the leukemia incidence rate increase.

4.Inherit a factor

There is the outbreak rate Gao of the crowd leukemia of chromosome mutation at the normal person.Such as 21- three bodies comprehensive advertise for of suffer from son at 10 years old in the outbreak rate of leukemia is 1/74, Bloom comprehensive advertise for at 26 years old in outbreak rate is 1/3, Franconi comprehensive advertise for 21 years old in outbreak rate is 1/12.When the family has a member to take place a leukemia, the probability of the its close relative occurrence leukemia compare the Gao of ordinary people 400%.The single egg double living medium suffer from an impatient leukemia such as 1, another incidence rate is 20-25%.The above fact all hints that the cause of disease of leukemia probably relates to heredity.

The recent years research confirm that the number abnormalities such as increment or decrease etc. of chromosome amount, and easy, set upside down, imperfection etc. structure abnormality, make the structure, expression abnormality of gene.Gene expression with/or lose of gene's live be one of the foundation that the cell is bad to change.