The You door Luo rod bacteria infects with stomach cancer

BE discover a You door Luo rod bacteria(H － pylori, Hp) before, to the occurrence of the stomach cancer thought to be turn into by the shallow form stomach inflammation to the chronic to atrophy sex stomach inflammation, again through bowel top the skin turned to living, and took this as foundation develop composition turn a gland cancer, namely pathology up hermeneutic stomach cancer many stages cancer-causing hypothesis.After the ear along with confirm that the Hp is long-term to keep on an infection and can cause chronic stomach inflammation, more enlarged a Hp infection is taking place stomach cancer the last meaning.Japan that deliver much in the stomach cancer, further of the research discover Hp infection not only for divide a gland cancer, is a huge dangerous factor towards DOing not divide a cancer also.Someone reports that the agree with stomach cancer sufferer lasts about 8 years of with visit a result to call, the Hp male set stomach cancer incidence rate reaches to 2.9%, but the feminine gender set have no stomach cancer to take place.There is also report, carry on an observation to the earlier period stomach cancer sufferer who once accepts to glue film resection inside the bottom of the mirror, go among them in addition to Hp therapy set don't the one who see to have a cancer to change inside the mirror reexamination, but is going in addition to the germ treatment set then has 9% to re- discover stomach cancer.These clinical observation results express that pass Hp in addition to germ treatment is can attain prevention stomach cancer.

The animal test

In the foundation study aspect what to acquire definite evidence at the beginning BE, the sand rat keeps on an infection can with the result that atrophy sex stomach inflammation and cause bowel a top skin to turn to living.The Hp infection can cause cancer alone this is doubtless a great problem and the report way is current to affirmatively also have the negative and still have no united views.It for one thing is, although have a report to call Hp the infection caused tumor kind a pathological changes alone and depend on in addition to germ therapy but get disappearance, to the stomach cancer of the sand rat diagnosis standard put forward to query.Hence turn but applied chemistry cancer-causing start experiment the sand rat cancer-causing model, discover as a result Hp infection can not only induct a low mark to turn a gland cancer, and again can obviously promote the occurrence which didn't divide a cancer.

General of cancer-causing process is divided in to call cell change of do"start function" as the transformation process of tumor, with call tumor of do"promote function" a growth process.Know to all, the Hp holds some Maos Mao can born ammonia, give the big rat hurl use chemistry cancer-causing MNNG, throw again to ammonia water, then it is thus clear that cancer-causing rate ascension, but throw over a long period of time alone to also and unlikely take place cancer, even throw alone to ammonia water over a long period of time, throw again to together and alone throw to compare to the MNNG set to the MNNG animal, its stomach cancer incidence rate as well indiscrimination.Can confirm thus, ammonia not start factor but only have to promote a factor function just.Just had researcher to once report a way to make use of chemistry cancer-causing MNU to Hp infection the sand rat started experiment enunciation, after infect Hp behind throwing to the MNU or the hurl to the MNU wented infection Hp again, all equally can lead to stomach cancer, so think Hp since have to promote a factor function and have start factor function.

Molecular biology

Hp infection with the result that the cancer-causing mechanism of the stomach cancer together other organs chronic burning disease is similar, on the other hand is burning the disease cell free radicals and inducement type an oxidize nitrogen born Mao(INOS) output of on oxidizing nitrogen(NO), and live oxygen and NO bornly call DNA of do"lead oxidize second nitrate" harm material, can injure cell DNA;BE on the other hand the chronic burning disease process result in of the cell period Kang enter, can with the result that cell DNA the replication be false.These all probably promote the risk that the cancer change.The experiment express that experiment inside the outside of the body and body in, the Hp all can induct stomach to glue the film top skin cell Diao Wu, as a result calculate Hp probably directly urge a cell period to appear Kang to enter.

Concerning the particularity mechanism of stomach, always think the N － second nitric Ji compound is one of the factor which hurts stomach to glue the film top skin DNA, but the Hp infection make stomach acid's secrete be thus suppress, can make to have second germ of ability of the nitrate revivification to be propagate inside stomach, hence cause second nitric Ji compound born increment inside the stomach, in addition consider be also likely to be because the INOS guides rare NO with the result that the stomach glues the film top skin DNA damage.

The Hp born CagA(the related gene of the cell toxin, the associated gene of the cytotoxin － A) egg white, is recognize at the beginning to make is to turn the toxin(VacA) related egg white with the cell empty bubble, its molecular biology meaning once wasn't clear over a long period of time.There is Epidemiology investigation report, CagA male germ stub infection compare the feminine gender germ stub infection the stomach cancer incidence rate obviously increases Gao.Still there is research point out, the stomach cancer of the serum antibody masculine gender of CagA egg white, especially divide an outbreak risk of stomach cancer big.

Know the recent years just discover, imply the CagPAI germ stub of the CagA gene take of set, can lie MAP to arouse Mao to activate signal conduction system but make the cell propagate.

Will prospect in the future

Comprehensive above-mentioned data to see, the close cause and effect relation of of Hp infection and stomach cancer outbreak seem to be already doubtless.But take germ about 6000 myriad peoples for existing Hp in Japan, but the year of stomach cancer be taken bad several about 24 myriad peoples but speech, also far come short of enunciation Hp to infect alone can be stomach cancer outbreak the degree of mechanism.Moreover see from the world scope, still exist the Hp infection rate Gao but its stomach cancer outbreak rate than Japan low nation.Still have, the HP stub of Japanese infection is almost whole is a CagA masculine gender and VacA masculine gender of, but the stomach cancer incidence rate also still has high region with low region.So, should think in occurrence and development of the stomach inflammation and the stomach cancer don't only have a germ on the other hand of factor, also need to be have with the result that cancer character and immune system is the factor of the representative's machine body, then ability again and everybody's life style, among them regard food factor as principle of the environment factor be related.

In the environment factor, can polish the stomach that the Hp induct to glue a film with the habit article factors, such as the food factor and the smoking, coffee, tea and wine...etc. burning disease respond, namely probably become promote of stomach cancer factor or prevent°from factor.For example, is investigated a hint by the Epidemiology, early think to smoke fish probably and together stomach cancer that the outbreak is related.The author confirm that the infection Hp sand rat animal feed in the fish powder contain may become the worsen factor that the Hp inducts stomach cancer, and also point out absorb to smoke the fish indeed has already make the Hp induct stomach inflammation bad change of possibility.

On the other hand, and then there is adoption medicine repressing a stomach inflammation disease to prevent stomach cancer from take place and develop of try.The recent years clarify, the wreath oxidizes Mao 2(COX － 2) and its outcome prostaglandin(PG) at digest way occurrence and progress of the cancer up have an important function.The non- Zi body anti- burning medicine(NSAIDs) over a long period of time take stomach cancer incidence rate and death rate of a large intestine cancer all and together is similar and can present to obviously lower.Hint from here, the NSAIDs anti- burning effect may be agree with stomach cancer of the occurrence has already repressed a function.Therefore will still there is necessity continuing to carry on from now on with repress a burning disease for target of the stomach cancer prevent°from a foundation research.