Prevent°from of prostate gland cancer

The prostate gland cancer is in the United States currently is one of the most familiar malignant tumors in addition to skin cancer.Add case 20 myriad peoples annually, die 3 myriad peoples.A great deal of data shows the close connection of the take place of male hormone and prostate gland cancer;Other dangerous factors still include heredity, race, food and environment factor etc.;Medical science field up to the present still have no valid prevention with thoroughly cure of that paroxysm method.Because the prostate gland cancer has outbreak rate Gao, hormone dependence, incubation period long, local area and race difference, prostate gland especially different ntigen(PSA) lump mark etc. characteristics, prevented research from provide for the cancer the best choice.A great deal of of the prostate gland cancer prevention study now under way medium;Among them part already early see a result, although still someone put forward different standpoint, the corpus think that the prevention of prostate gland cancer is viable.



5 α－s restore Mao depressant



The research which has another in the last years confirms that the male hormone(particularly is a pair of hydrogens Gao Tong, DHT) has in the outbreak process of prostate gland cancer a decisive function.Although the male hormone cancellation therapy is very valid, because it cans cause male feminization, the breast bulge side effects such as pain and sexual function obstacle etc., so is subjected to certain restriction in the application of clinical top.So the sufferer urgently hopes acquire side effect a little prevention method.Study an observation detection, the hereditary II type 5 α－ revivification Maos lack a disease, the sufferer doesn't easily suffer from positive prostate gland hypertrophy(BPH) or prostate gland cancer, this phenomenon urges the scientists to develop 5 α－s revivification Mao depressant a creation interest.There is another research detection, the double of the African Americans American hydrogen Gao the Tong restores Mao level with 5 α－s obviously higher, the cancer incidence rate of its prostate gland with from here the death rate cause be as well higher, should express 5 α－s a revivification as a result the Mao depressant has a latent prostate gland cancer a prevention a function.5 the α－ revivification Mao the depressant can stop the conversion of Gao Tong as a pair of hydrogens Gao Tong.Double hydrogen Gao the Tong urge prostate gland aggrandizement and cause thus BPH and prostate gland cancer, so 5 the α－ revivification Mao the depressant cure and prevent°from the reasonable choice of the prostate gland paroxysm.



Deepen(finasteride) a type of new selectivity II type which develops to develop in the 90's for the American Mo4 Ke4 company 5 the α－ revivification Mao depressant, can show Zhao to lower a pair of hydrogens Gao the level of the Tong.Not that male An in order to cure BPH have already obtained affirmative curative effect, the result manifestation of a "the aroma Zi Tong long-term curative effect and safety study(PLESS)", in 4- years placebo check against experiment, not that male An(5 milligrams/ per day) can contract a prostate gland physical volume, increase urine to flow a rate, lower prostate gland symptom grade point, and show Zhao to lower BPH a sufferer impatient urine the Zhu stay with the risk of surgical operation.In another placebo check against the research, 120 sufferers who accept a prostate gland cancer to cure for good Shu adopt not that male An a treatment(10 milligrams/ per day), result show not that male An can defer serum PSA level to go up and postpone to relapse.After not that male An curing for 12 months, sufferer the PSA level value increment defers for 9 months;Cure after 24 months, the its PSA level value goes up and can defer for 14 months.Someone at to application not that male An prevents the collection of the prostate gland cancer from carry on review analysis after discover, sufferer through not that male An treatment after, its serum and the hydrogen Gao Tong level of the double within organization are all lower, and serum PSA the level can also lower.This probably increases to living to the control prostate gland with prostate gland cancer the development have an important function.



Because the selectivity II type 5 the α－ revivification Mao the depressant(not that male An) has in the aspects of prevent°from prostate gland cancer can pleased foreground, the American national cancer, graduate school(NCI) is to a research which is named "prostate gland cancer prevention experiment(PCPT)" provide subsidize with the assurance not whether that male An can lower the occurrence risk of the prostate gland cancer or not.Up to February, 2003, totally there are 16296(86.3%) test-receiver completion experiment.The research discover that compared with the matched control don't lower the outbreak risk of the prostate gland cancer 25% for that male An(5 milligrams/ per day)7 years.Be prevent°from sex medicine, not that male An have to goodly bear to be subjected to sex;Discovered up to the present that male An doesn't have a serious medicine related safety worry.



However the PCPT be the medicine prevention of the prostate gland cancer of a big sample to experiment a research, through series screen and prostate gland live the check assurance prostate gland cancer outbreak rate to exist to screen out have no clinical meaning of pathologic period prostate gland cancer of possibility;Its prostate gland cancer checks a rate Gao in usually outbreak rate.Not that male An set research shows to have already increased high prostate gland the risk of the cancer as a result, and existence certain degree of to the influence of the sexual function.Therefore and not that male An's ising the prevention medicine of the prostate gland cancer is still treat in further research, and should weigh an usage according to the clinical individual circumstance.



Vitamin with little chemical element



The vitamin E is a kind of valid anti- oxidizing agent.In the animal the experiment, the vitamin E can repress high fat food to grow a function to the Cu of prostate gland tumor.The selenium is the little chemical element of indispensability in the human body life, can once obstruct the formation of the oxide and the free radicals and repress the occurrence of various cancerses thus.The selenium, the vitamin E of γ－ , the vitamin E of α－ which studies detection Gao level can reduce the outbreak risk of prostate gland cancer;Blood plasma γ－ content the tallest male of vitamin E and content the lowest male compare of the prostate gland cancer contract a rate and can reduce 500%."The cancer prevention of selenium and vitamin E experiment(SELECT)" is a NCI to subsidize of another large-scale prostate gland cancer prevention research item, aim at explicit vitamin E and selenium whether can lower the prostate gland cancer of healthily male community an outbreak dangerous.Should study item to begin from 2001, expect to complete to 2013;32400 anuses' diagnosing prostate gland normally level is normallynormal(<4 milligram/rise) with blood plasma PSA of the male accepted inquisition.The III period clinical trial result that is under way show, both all have latent prevention prostate gland the function of the cancer.



The vitamin AN in the food contains various forms, among them the carotene of β－ , foreign lycopene and prostate gland cancer of the connection research be the most.The research confirms β－ the carotene absorbs the risk that the quantity lower suffers from a prostate gland cancer to increase Gao.American latest Epidemiology investigates to discover and usually eating tomato ware can lower a risk of suffer from the prostate gland cancer.The researcher discovers after drink together the food in of a time the lycopene content the calculation that the day absorbs the risk that 18789 tiny grams of foreign lycopene contract a prostate gland cancer to absorb for the day 3415 communities of 0.8400%;Discover to eat 1~2 ketchups every week in the meantime of the community contract the risk of prostate gland cancer to eat a ketchup community just for every month of 0.7700%.The tomato ware still keeps exist after expel factors, such as edible other fruits, vegetable and olive oil...etc. to the protection function of prostate gland cancer.Although hard break to settle whether this kind of protection function is only or not to relate to foreign lycopene, the experts still recommend public to eat tomato ware more.



A great deal of research confirms that the exaltation blood plasma vitamin D metabolizes a thing and can consumedly lower the risk of prostate gland cancer.The biology live form － bone of vitamin D's turning three Chuns(1, 25 －s two Qian vitamin D3s) is the main calcium in the body to regulate one of the hormones, can repress mankind the propagate of cell of the prostate gland cancer and divide.The Epidemiology investigates a manifestation, African Americans American prostate gland cancer outbreak more probably with deep color skin disadvantage in inside the source vitamin D synthesize related allied;The sunlight projects light upon quantity of how much with prostate gland cancer of the occurrence present negative related;Blood plasma bone's turning three Chun levels to lower is a prostate gland cancer the dangerous factor of the outbreak.The bone turns the anti- tumor of three Chuns although the function has already got a confirmation, the super physiology quantity application can lead to Gao Xie3 Gai4, Gao Niao4 Gai4 and kidney stone calculus.Therefore, it is some to have stronger anti- tumor cell to propagate function but less with the result that the vitamin D of Gao Xie3 Gai4's side effect similar thing has already caused biggest pay attention to of people.Turn through a bone currently three Chun side the modifier of the chain has already developped a many bones to turn three Chuns similar thing and all express the separation that an anti- tumor cell propagates a function and Gao Xie3 Gai4's function.In fine, the bone turns the applied foreground of three Chuns can because the proper anti- propagate, the Cu divide with induce Diao Wu function but become more for the amplitude;It more detailed anti- tumor function mechanism research and it is similar the development of thing study now still carry on in.



The food interfere



In many dangerous factors, what to have prevention meaning most is the food factor which inducts a prostate gland cancer.Hot quantity the food can lead to a series of of healthy problem, such as obese, diabetes and high cholesterol blood disease, and therefore influence to take Gao Tong as the representative's male hormone Gao Di of the level.The body quality index number(BMI) which in order to reflects fat degree can be absorb by heredity, total calories, basal metabolism, sport quantity etc. the influence of various factor.A great deal of research confirms that the high BMI relates to the risk increment of the prostate gland cancer.



Low fat food's ising the aggressive intervention measure which lowers the occurrence risk of the prostate gland cancer has already been confirm.American San Francisco of Chinese immigrate and the prostate gland outbreak rate of Japanese emigrant want compare native person Gao 3~700%, the very important factor of an among those is a high fat content the food be opposite to take more.Beyond all doubt, west nation of the crowd prostate gland cancer outbreak the rate be obviously high national at the east.The "the second consultation committee with international prostate gland cancer" report for convene in Paris point out, the prostate gland cancer outbreak rate of whole world is compute with 100,000 male populations, Chinese Shanghai be lowest, is 2/100,000;The American black is the tallest, is 137/100,000;Twos differ 6000% of many.Investigate its reason, a little bit more very important namely with the food structure of the west of the east difference relevant;The usually western food fiber is little and the fat is many;But the eastern meal fiber be many, the fat is little.Many researches confirm that excessive fat's absorb is a prostate gland cancer the key place of the outbreak, because the fat composition is excessive, the cholesterol in fat inside the human body namely converts into estrogen, particularly is the comparison which converts into Gao Tong to suddenly increase;The increment that the outbreak of prostate gland cancer exactly measures with male hormone is closely related.



The research of phytoestrogen discovers to have importance value.The phytoestrogen which comes from soybean, corn, fruit and vegetable etc. includes the flavonoid material(flavonoids) of the isoflavone(isoflavone), type a vegetable(lignans) with wood fat, they all have weaker estrogen activity.A great deal of research detection takes a meal bean, fruit and corn and can lower the occurrence of various tumorses and include a prostate gland cancer.These phytoestrogens can repress 5 α－ revivification Mao, fragrance to turn Mao, the Lao ammonia sour particularity egg white to arouse Mao.The DNA of activate carries a grain of Mao to have to repress afferent formation and anti- oxygenation, end repress the occurrence of tumor.The Epidemiology investigates result enunciation, the clinical prostate gland cancer of the western and flourishing nation the death rate be obviously high at the Asian crowd;Although the excessive animal fat absorbs probably with prostate gland cancer of outbreak related allied, someone is three to Japan, Finland, the United States nations carry on of investigate manifestation, though Finland residents' high fat meal absorbs to differ with the United States only a few, but the prostate gland cancer outbreak rate of crowd is low at the United States but Gao in Japan.Wet total phytoestrogen level in liquid to carry on an examination to three residents of nations, show as a result Japanese residents Gao are in Finland and residents Gao in Finland are in the United States.The isoflavone which has the Japanese male of traditional food habit absorbs quantity about 20 milligrams/ per day, but the isoflavone of western and national male take quantity to return not enough 1 milligram/ per day;With Japanese male blood plasma high level dyestuff wood flavonoid(180) with western and male blood plasma the low level fuel wood flavonoid(<10) be mutually consistent.



The prostate gland cancer outbreak rate of eastern and national residents is with food low to absorb according to the soybean egg white food of soybean more relevant, because have in this kind of food abundant phytoestrogen, to the male hormone certainly repress a function.Whereas, the soybean egg white food once absorbed little, the its beneficial factor will die down or disappear and foster male hormone thus after the influence of the hair prostate gland cancer.