The oesophagus cancer is a familiar kind of the mankind malignant digest way tumor.World male, the female average death rate distinguish to 2.5~5.0/100,000 with 1.5~2.5/100,000, seriously endanger people's health.The Epidemiology data show that the smoke, wine are the main and dangerous factor that Western Europe and oesophagus cancer in North America take place, but the meal lack vitamin, second nitrate content to increase Gao and food fungi pollution etc. probably have something to do with occurrence in the Asian central part, region and Chinese oesophagus cancer.Along with the development of molecular biology, discover in the oesophagus cancerous occurrence the development the process to involve to several changes of genes, so, the oesophagus is cancerous of the occurrence may be various results that the factor synthesizes a function.
Biology cause of disease
Mankind nipple lump the virus(HPV) be a kind of DNA tumor which loves up the skin cell virus and relate to with oesophagus cancer more and closely.There is research think, the HPV16 type relates to the oesophagus scale cancer occurrence and the HPV18 type has relation with oesophagus gland cancer.In recent years, along with the development of member Epidemiology, discover that the HPV has to enlarge myc and the H － ras function of the cancer gene C － , and can make to suppress cancer gene's p's 53 mutations to lose to live.These all explain the HPV infection may develop to emphasize to want a function in the occurrence, development of the oesophagus cancer.
The fungi infect.Discover in the oesophagus cancer Gao Fa Qu with lowly the hair the area of the contrast the research, the oesophagus cancer corn fungi pollution rate of Gao Fa Qu is obviously high in low hair area.Discover the food of Gao Fa Qu while carrying on separate and authenticating to the fungi in the food in of with each other separate to hand over the bead sickle germ of the chain Bao mildewed, string, smoke song's pollution of the mildewed more widespread.This probably with fungi not only the ability restore nitrate second nitrate, also can resolve protein, increase the content of An in the food, promote synthesize of second nitric An relevant.
Second nitric An
The second nitric An is a kind of very strong carcinogen, extensively is distribute in mankind a living environment in, and can synthesize still in the human body under the function of fungi.The second nitric An carried on in the rightness the oesophagus cancer outside environment inside the body of Gao Fa Qu residents and it before the research result of the body thing system enunciation, the mankind oesophagus cancer has close relativity at the second nitric An compound.Have already discover now 10 various second nitric Ans can especially the foreign land induct an animal oesophagus cancer and have obvious of organization close with sex.
Social economic condition
The oesophagus cancer Gao Fa's region, mostly poorer region, and social stratum and oesophagus cancer be closely related.These factors mainly include marital status, is subjected to level of education, occupation, income and whether be placed in poor level etc..The research discover that the oesophagus cancer danger of the outbreak along with residents income level of increment but descend.Generally say that come, low level person all the income be low, the its home life level, nourishment condition, medical treatment hygiene's condition is all worse, is various factor comprehensive result of influence.
Living food habit
There are various carcinogens in smoke and tar of cigarette, such as benzene combine Bi, many wreath Fang hydrocarbons, second nitric Ji compound, wreath oxide...etc., these material ability the direct function results in the cell hurt at the compositions, such as cell protein and nucleic acid...etc. and cause a cancer to change.The smoking is the oesophagus cancer dangerous factor already drive affirmative, suffer from the danger of oesophagus cancer along with smoke cigarette to measure of increase, the smoke age increases but increases Gao, return with tobacco of category, whether quit smoking relevant.
The relation conclusion between alcohol and oesophagus cancer is still inconsistent.There are research detection, oesophagus cancer and alcohol measure, alcohol of the violent degree has an obvious quantity a － effect a relation, and the of smoke wine have to be in conjunction with a function.At analytical food factor to oesophagus cancer function discover, influence the oesophagus cancer high hair of the food dangerous factor for preserve ～ in salt the article absorb excessive, pleased food very hot the food, fresh fruit and vegetable once absorbed little, food rough, high salt food, hot tea, hot food with quick food etc. badly make it a rule.
Nourishment factor with little chemical element
The occurrence of the meal nourishment and oesophagus cancer is closely related.Discover while absorbing horizontal analysis to the oesophagus cancer meal nourishment in the state City vegetable of Gao Fa Qu wood, the meal protein of the ground's residents absorbs quantity low, and the source be not reasonable and mostly come from food corn, animal and bean egg white to have a comparison smaller, the vitamin A, B2 absorb shortage.
The relation between little chemical element and tumor has already been subjected to people's concern more and more.A lot of researches proved some and little chemical element selenium, zinc, copper, iron and calcium are in the body and the variety of the content in the soil and the occurrence, development of the oesophagus cancer be closely related.
Mental factor
Most researches express that the spirit wound history, motion are worried to have increment to suffer from an oesophagus cancer in recent years of dangerous, negative sex life affairs if lose spouse, family members' heavy disease or pass away, economic condition depravation or over a long period of time be placed in melancholy appearance can make the risk of oesophagus cancer increase.This probably should arouse appearance with person to pass to lie the comprehensive function of mechanism but cause a series of bad physiology variety in the quality and immune system etc. through a plant nervous system, endocrine system, nerve and break a machine body an immune system thus of from steady state relevant, but machine body immunity function of lower, and then is a cancer occurrence and development of one of the essential conditions.
Inherit easy sensitive faculty
Generally think tumor of the formation be the result of environment factor and the interaction of the heredity art, but the inherit of machine body easy sensitive faculty be the internal factors of outbreak.At oesophagus cancer Gao Fa Qu, often discover that some households gather together phenomenon, and much concentrated between the blood relationship relatives, the hint's heredity's factor includes in the oesophagus the cancer of the occurrence certain function.
Along with the development of member genetics, cell genetics and it is in the tumor the research the realm of extensively applied, the domestic and international scholar is from the gene and the chromosome level to oesophagus cancer of the cause of disease carry on a thorough research, discovered various meaningful genes, for example because of p 53, the Rb suppress cancer gene of mutation or miscellaneous match sex imperfection, but influence it to normally grow, develop, divide medium function in the cell, cause the cell cancer change.Some results all prove that descend from the preceding generation heredity go to of don't be a tumor, but inherit tumor easy sensitive faculty.
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