The hormone and chemistry treatment of the prostate gland cancer of latest make progress

Because the extension of the life span and the west of the food habit turn, is thought that the old people's patent-prostate gland cancer also silently becomes the cutthroat of male people before.Its bane to the our country male patient allow of no to neglect.Particularly is a prostate gland particularity in blood because of the diagnosis technical progress recently antigen(PSA) extensively applied at the routine check-up, consumedly raised earlier period prostate gland cancer of diagnosis rate, then also raised prostate gland a cancer of cure rate.But can't Hui speech of, still have the patient of one part is already a later period at the time of being check, or after surgical operation cut off again relapse an assignor even.The prostate gland cancer cell is for the equal sensitive of the male sex hormone, so choose for the hormone therapy to the treatment head of this later period patient, be also the function which stops the male sex hormone － testicle Tong cell to the prostate gland cancer and then attain to repress increase of cancer cell to living and the anti-cancer effect for transfer.The hormone therapy apply not outside at the treatment direction of prostate gland cancer(1) the way cut off by testicle directly stops the manufacturing source(2) of testicle Tong through the interference or resists yellow body hormone to release secrete of hormone(LHRH) but attains a manufacturing(3) of lower the male sex hormone through repress 5 －α－ revivification Mao but turn down testicle Tong inside the prostate gland organization to convert activity of two hydrogen testicle the Tong(4) stop two the hydrogen testicle Tong and the male sex hormone of prostate gland cell be combine by body.



Therefore at above-mentioned hormone function of the four kinds of arrestment male at prostate gland cancer cell of under the thinking, the hormone therapy can induce following few kinds:



A, the traditional testicle cut off, or the effect be equal of the LHRH the same kind thing inject, book from stop pituitary gland to secrete yellow body hormone, then reduce the manufacturing of testicle Tong.



Two, recently for the sake of decrease continuously sex LHRH same kind side effect that thing cause when cure such as face the tide be red, the sexual appetite lower, erection can't, bone soft etc., by fits and starts of the sex hormone therapy(steroid Flutamide or not steroid Casodex) of the usage anti- male and the LHRH same kind thing and the anti- male sex hormone medicine merge therapy drive as well gradually extensive usage.



Three, use the anti- male sex hormone therapy to appear symptom to just use than the patient in advance, want after wholely preparing to have to be good.



Four, anti- male the sex hormone merge the depressant therapy of 5 －αs revivification Mao, the direct nti- LHRH therapy,such as abarelix, still carries on a research currently medium.



However still have part of patients will appear the invalid circumstance of the hormone therapy, be called the male sex hormone doesn't depend on the independent prostate of the Androgen － of the prostate gland cancer of type cancer(AIPC).



For the treatment of AIPC this type of patient very tough and have a challenge, on the other hand the patient's course of illness equal later period, have no on the other hand better rescue therapy.The AIPC effect for traditional last chemotherapy is very and limited, mainly is a prostate gland cancer the cell all presents a drug-resistant to various chemotherapy medicine and the toxicity of chemotherapy will let the patient's condition of patient snow up add frost in the meantime, didn't receive its benefit, is harm by it first.Canadian till 1996 of the Tannock doctor announce of the research show with anti-cancer turn the steroid that the thing mitoxantrone pluses low doses can availably ease the AIPC patient's symptom(especially ache), significantly raised the patient's quality of life, although can't prolong life span, open a window to the patient who cures AIPC with the chemotherapy, and encouraged to cure the boundary further research.In the anti-cancer medicine of numerous new generations, compare what quilt notice is a yew Chun and include Taxol Tai a gram Suo(be so called American yew Chun) and Docetaxel.(the cancer of Taxotere 剋 easy, be so called European yew Chun)In spite of turn in the anti-cancer pharmacology machine and body outside of experiment to all have very quite good effect.But if compare Taxol and Docetaxel, the Doxetaxel then is again stronger than Taxol efficacy of medicine, as a result the Docetaxel is think to be the new hope that the chemistry cures a prostate gland cancer.Finally announce in 2004 new England medical science periodical is got the research of soldier by the Petrylak doctor to show that the Docetaxel pluses an estramustine(suppress a cancer) combination not only effect a ratio mitoxantrone+the steroid is good friends with in easing symptom and lowering a PSA density, and can prolong the patient's life span equally many 20%, this important clinical trial breaks a chemotherapy as a result and not only and should not use in the later period prostate gland cancer of enigma, especially to hormone invalid patient, more established the Docetaxel cures in the prostate gland cancer in later period of role,



As for the chemotherapy of the future develop, doubtless of regard Docetaxel as principle, again match other medicine, for example live Calcitriols of the vitamin D3, afferent and new-born depressant such as sand benefit the Dou exceed(thalidomicle) the bevacizumab of the anti- VEGF mark Ba treatment, or the anti-cancer medicine epothilones of new development, we expect the result of these clinical trials, probably can benefit more prostate gland the patient of the cancer and reduce their pain and sufferings.