Child's leukemia

The cancer is the second reason which results in the child die, but the leukemia be the most familiar cancer in the pediatrics, basis Taiwanese child the covariance of the cancer foundation, only there are annually 125 sick kids in Taiwanese region contract impatient and lymphoid but blood disease, 40 sick kids to contract an impatient marrow leukemia, 3 sick kids to contract chronic marrow a leukemia, each 27%, 9% and 0.7% which have that region children's cancer to suffer from a new outbreak example for whole year.

Although currently leukemia of real with the result that cause because of still not clear, still some inducements relate to it and include an environment factor, heredity, virus and immunity factor etc..The clinical research discover revelation while project the line(such as World War II after, Japanese wide island and the luckily survive of Nagasaki or embryo expect and then accept to diagnose pity project line etc.) of patient, take place leukemia of opportunity increment.Moreover some hereditary diseases and congenital color epidemic disease not the patient of whole symptoms, the opportunity to contract a leukemia increases Gao.But together when egg 1 in the twins contract a leukemia, another opportunity to get a leukemia increases Gao.Same of, virus also the companion play a certain role, like the lymphoid lump of mankind T and the leukemia virus, EB virus...etc..In addition, chromosome abnormality and carcinogen are to the formation of leukemia and also the companion play an important role.

50's ago, just with support rapy, the sufferer who has above 90% will die in six months, the leukemia is counteract with the variety anti-cancer medicine now, to the prevention of central nervous system leukemia, plus a progress of support the therapy, local result is:The impatient lymphatic leukemia of standard cluster alleviates the rate as 96%, 5 years, have no disease livability to 72%, treatment time the beard be 2.5 years;High and dangerous cluster of impatient pour alleviate of sex leukemia rate as 88.5%, the five years ﹑ is 48% without the disease livability, treatment time the beard be 2.5 years;The impatient lymphatic leukemia of very high and dangerous cluster alleviates the rate as 80.7%, 2.5 years, continuously alleviate the rate as 5205%, time of treatment the beard be 2.5 years;The impatient marrow leukemia alleviates the rate as 68%, continuously alleviate the rate as 40% for a year, time of treatment the minimal beard a year, transplant for the marrow after had better reach to alleviate, the long-term livability just can increase to 50%.

So the child leukemia has already been no longer see as the terminal disease, can acquire this result is be attributed to various biotechnologies quickly make progress and cautiously observe to a handful of clinical case treatment reaction analytical experience accumulation since then of, these are all develop by small scaled research to large even is nation or international common research get of experience;Various cancer of year the hair rate be little, its treatment result has to include full case number and 3-5 years above observation time, just good enough to judge some sex of treatment project;If alone from individual organization research, finally is time-consuming ﹑ hard to tackle and usually can not compare with time limited efficacy, the domestic works on a child blood tumor a treatment of under this consensus, the experts hope to be common to use same treatment mode..

But know some patients as a result by same treatment project treatment can exist but cure over a long period of time, have of but hard completely alleviate or after short date alleviate namely again relapse but die.The leukemia is a flock of complicated disease, in fact the patient beginning deliver clinical token and laboratory data and patient can recover from illness to have a very close view in the days to come allied;So want to attain an ideal treatment result, depend on in advance characteristic of aim at the patient and do the set of cent treatment, for more empress worse high and dangerous cluster, give stronger treatment, can promote its cure rate, for can attain an ideal cure rate with the appropriate treatment, but unlikely increase after preparing better standard cluster possible take place in the days to come of erupt the unnecessary toxicity in the treatment process of disease and decrease to respond.

The treatment divides three stage ﹕s

1. The leading alleviates to expect the ﹕ makes use of an anti-cancer medicine to kill cancer cell, about 4-6 weeks, cancer cell inside the marrow declines to below 5% and call that it alleviate.

2. The consolidation expects the ﹕ to change other anti-cancer medicine and kill to conceal in the cancer cell in the body.

3. Maintenance period ﹕ keep on anti-cancer 1-2 and half years medicine treatment, kill all cancers cells for conceal inside the body, make it no longer relapse.

Do the prevention of central nervous system system treatment in the meantime at this stage, periodically take out a spinal cord liquid check, and is infused into anti-cancer medicine by the spinal cord chamber, parts of individual case beards accept a Lu department to put a line treatment to prevent cancer cell from transfer to the central nervous system system.

Before cure have the central nervous system invasion, is less than 5% at the impatient lymphatic leukemia, but the impatient bone bone leukemia is 5% to 14%;At the under medical treatment, the ratio that the leukemia infringes upon central nervous system happen monthly, their homology;If don't give the treatment of special central nervous system prevention, 85% impatient lymphatic leukemia ends will have central nervous system invasion, the impatient marrow leukemia is in this aspect of although the ratio be low, is because of time of survival shorter past;Give currently valid central nervous system prevention treatment, the central nervous system relapses a rate to decline to 5% to 10%;Central nervous system after relapse, usually immediately after would the marrow relapse.

Cure a male and impatient lymphatic leukemia currently, relapse of pill rate for 10% is to 16%, but if cure of ex- six months, use several Gao Ji4 Liang2 MTX, the pill of the 睪 then relapses a rate to decline to 1%.When pill relapse, the liver Pi ﹑ belly lymphoid knot often had leukemia invasion, so sometimes immediately and immediately after the marrow relapse.

Central nervous system or pill after relapse, if the marrow relapsed, then the part emanation line project light upon, besides which, still the beard again gives leading the alleviate type intensive chemotherapy for 4-6 week, need not more make stronger the chemotherapy of period type again, the maintenance expects a type of chemotherapy still the beard be a year;If the marrow relapse, the whole chemotherapies then do it again and the beard is 2.5 years;The central nervous system emanation is maintain to expect to do, two side the pill project line to project light upon 2400 thunders is in the leading to alleviate to expect to do.

Currently the treatment of leukemia's ising guide to expect to attain to alleviate has already not a problem done not relapse a livability over a long period of time for the sake of the increment, in addition to maintain the period cure, point more the beard put in the consolidation to expect and high and dangerous cluster of again strengthen a treatment, hope can even improve a prepare of leukemia after and exaltation treatment rate.