The cause of disease of liver cancer breaks to translate

Within the scope of world, the liver cell the outbreak rate of the liver cancer(HCC) has the 5th of the cancer swollen outbreak rate and its death rate has the 3rd of the cancer swollen cause of death.Distribute to see from geography, the HCC high hair niche is in East Asia, medium not and the west be not- some nations, but North Europe, Australia, New Zealand, north Gao Jia Suo3's region and Latin-American HCC outbreak the rate be lowest.Male HCC outbreak rate Gao in the whole world is at the female, the sex compares to 1.5 －s 3.0 ﹕s 1.HCC prevention and cure, the point lies in one class with second class prevention.
Concerning the HCC cause of disease, generally think that B liver and C liver virus infection is a main dangerous factor, among them B liver virus(HBV) is the main cause of disease of developing country, but C liver virus(HCV) is the main cause of disease of flourishing nation, two consociation with the result that of the HCC have above 80% that the HCC is taken bad a number.Other dangerous factors,such as alcohol, yellow song syphilis plain B1(AFB1), Japanese schistosome, chlorine ethylene(VC) and water pollution etc., also are valued.
B liver virus(HBV) with HCC
The relation between HBV and HCC already a great deal of Epidemiology investigate analysis, laboratory and ecology a research to confirm.The WHO twice declares HBV in 1993 and 1997 for cause liver hard change and HCC important reason.Relevant HBV cancer-causing research of mechanism, have already put a point on the gene of HB × in recent years.Someone passes to turn the gene small rat to experiment certificate HB × gene can with the result that the change of the liver cell appearance and bio-chemical function combine end cause HCC.
C liver virus(HCV) with HCC
A great deal of serum Epidemiology investigates enunciation, HCC sufferer anti- － the HCV(+) check a rate obviously high at the healthy crowd.Someone confirms through the examination of HCB replication middle body in the HCC organization, cancer organization medium have a HCV replication, also examine HCV RNA in the HCC cancer change the organization.So the HCV hepatitis is obvious chronic turn tendency, easily turn into liver hard change, generally think that the liver is hard to change the HCV chronic infection that the sufferer win be HCC a dangerous factor, and hint that the HCV may have to directly cause cancer function.P 53 genes importantly suppress cancer gene, it all has already lost to live phenomenon in many cancers swollenly, and the HCV also are valued to p 53 functions.There is research enunciation, the C egg white can easily cure p 53 genes to transcribe, may be a HCV with the result that HCC important mechanism.Moreover hint in the rightness the research of the HCV NS3 egg whites NS3 the egg whites might be the source mechanism indirect function to make at p 53 genes in the liver cell the conversion the earlier period pass its mutation, cause thus liver cell the cancer change.
Alcohol and HCC
The inquisition enunciation of a great deal of Epidemiology in great quantities drinks alcohol to relate to HCC over a long period of time.Generally think that the surfeit alcohol often passes a fatty liver, the alcohol hepatitis and liver hard change etc. step, end cause HCC.American place"food, nourishment and the prevention of cancer" of the cancer research report a middle finger:The alcohol can not confirm to have a start the function of the cancer in the animal experiment;Moreover also only have 10% －s the 30% occurrence HCC in the alcohol the liver hardly become.In fine, in great quantities drink alcohol over a long period of time the fact of cause the HCC be authentic and its outbreak mechanism needs to be clarify.
Japanese schistosome and HCC
The Epidemiology research discovers that Japanese schistosome and HCC present to show Zhao just related, and Be confirmed that the Japanese schistosome is HCC a dangerous factor by further research.Clinical, the research of pathology and immunity etc. also supports this standpoint.In the rightness the research of Japanese schistosome cancer-causing mechanism, someone makes use of Ames to experiment to evaluate a Japanese schistosome to withdraw a guide of thing to change sex, discover that Japanese dissolubility antigen(SEA) of the schistosome egg has the Cu cancer of show the Zhao the activity.Think now SEA that day originally schistosome infection of the most important composition in the pathologic research, the SEA has strong antigen, can become schistosome egg proud flesh in the liver swollen, cause the sufferer die.The SEA still has strong with the result that quick original, love an acidity grain cell to tend to turn the factor live and neutral grain cell to tend to turn a factor activity.The above-mentioned living creature of the SEA is live to with each other interblend and cause various pathology that the infection cause respond.
Yellow song syphilis plain B1(AFB1) with HCC
In great quantities edible imply the food of AFB1 can cause HCC fact have already got a confirmation.There is particularity p in Chinese Qi east AFB1 in Jiangsu pollution area HCC specimen 53 suppress cancer gene a mutation.South Africa with Senegal of the AFB1 pollute the area also have an alike report way.BE have no Europe of AFB1 pollution, the Japanese etc.'s ground's this kind mutation be very rare.Moreover have a report way the liver cell of the person whom the body outside develops showed same p 53 genes a mutation after expose in the AFB1, so can think 53 genes: p of this kind and special mutation the form relate to AFB1.
Chlorine ethylene(VC) with HCC
As early as beginning of 70's in 20 centuries, the animal study and the proof which provided VC to cause cancer of the person's case report way.The Epidemiology investigates to still hint that the VC may be 1 kind mostly generally, the cancer-causing of many organs, can induct mankind's various tumors to include liver cell a cancer.Concerning the VC cancer-causing mechanism, the research that is in recent years expresses that the VC is a kind of carcinogen which has a heredity toxicity, in the cell dye together achievement Mao of under the function, the VC is metabolize to activate in to oxidize chlorine ethylene(CEO).The CEO has a heredity toxicity a function to various different living creature bodies.
Tiny bag Zao toxin and HCC
At the beginning of 80's in 20 centuries, someone puts forward the cause of disease standpoint that the drinking water pollution has something to do with the occurrence of the liver cancer.Because the water pollution and the liver cancer takes place particularity contact to really settle, the research which investigates carcinogen or Cu cancer thing in water hasn't been once breaking off.In recent years the blue-green algae pollution and the mankind in water's healthily relating to is valued day by day, the many report way is extensive to exist a blue-green algae in Chinese liver cancer drinking water of Gao Fa Qu and hint the blue-green algae pollution in the drinking water may be 1 of the liver cancer high hair with the result that the cause of disease is plain.China, Japan and Australia scholar's applying animal to experiment model has already confirmed the wreath form of blue-green algae creation seven Mao liver toxin-the tiny bag Zao toxin(Microcystins, MC) is the close liver Cu cancer of a kind of mightiness.
The HCC occurrence is many factor, many processes of steps.HCC a few dangerous factorses that this text say are only at present to study more thorough get a generally accepted cause of disease.Along with the progress of science and technology, continuously will there is new cause of disease disheveled hair now.There is report way call having already discovered a You door a Luo rod bacteria(Hp) an infection from the HCC sufferer's cancer change the cell.Currently Hp infection's ising the most cause of disease that the chronic stomach inflammation, digest ulcerate has already got consent of international medical science field and it is a dangerous factor of stomach cancer to also get a confirmation.The Hp all has a higher infection rate in the crowd of the flourishing nation and the developing country.If between Hp infection and HCC of the contact can get a confirmation, doubtless will have tremendous push to HCC prevention and cure function.Moreover, to the HCC have already known that the research of the consociation cancer-causing function of dangerous factor still needs continuously thorough, because any disease all isn't the result of single factor function.Although the HCC cause of disease is complicated, continuously makes great effort at the medical science science worker under, believe that the liver cancer certain ability is overrun.