Blood tumor Ba to treatment research make progress-the 47th American blood academic association(ASH) annual convention

The 47th American blood academic association the annual convention convenes in Atlanta of December 10-13, 2005 at the United States, with since go toward similar, the conference main contents includes to continue science of educate the academic chair, NIH to report with the thesis communicate several part.Continue to educate academic chair to take introducing each kind of blood disease diagnosis and curing a related research to make progress as a lord, science report main introduction some build related latest research of blood cell and blood disease progress.Relevant blood tumor Ba's studying toward foundation and clinical trial of treatment be an important topic.In addition to the introduction is some to have already apply or develop an applied series of and single gram Long antibody, and aim at a Lao ammonia sour arouse the outside of the research result of the thing of repress of Mao, this annual convention introduce of still have very main of a part of contentses are a research to aim at some cell Diao Wu etc. thoroughfare of related egg white translation level of stop a function, attain the treatment strategy of the function of anti- Diao Wu of converse the cell thus.



1, single gram Long antibody of applied



1.1 anti- CDs 20 single anti-s



The CD20 is the marking of B cell to divide antigen, express at the all B cell surface, anti- CD 20 single anti-s can availably Ba to CD 20+ B cells but apply at the B cell leukemia, many treatments of the hair cell leukemia and lymphoid lump etc..



Anti- CD 20 single anti-s(Rituximab, the United States Hua) are a treatment of personalization single gram Long antibody(single anti-), cure in the lymphoid lump of the application have been as long as 10 years, currently with 375 mgs/m 2 is standard quantity.But as to it's expand an application with how more excellent application for turn always is a topic of clinical research.Total of think as a result for the lymphoid lump patient:(1)Alone keep on a few months applied Rituximab treatment, its effect is similar to chemotherapy, but the side effect be very small, but keep on a treatment then can make stronger with extension what chemotherapy induce alleviate a period.The past single medicine keeps on an application to plan main recommendation to used for a condition to make slow progress and bears the patient of medicine to the chemotherapy.(2)Rituximab and chemotherapy unite a treatment and can prolong alleviate of the 20+ lymphoid lump of various type CD time, and can improve existence time of fill the air sex big B cell lymphoid lump(DLBCL).(3)Recommend apply the 375 mgs/m 2 Rituximab's conduct and actions before each chemotherapy period a glimmer of treatment the project treatment can cure of B cell lymphoid lump patient and the sloth lymphoid lump of high Wei.



Rituximab same drive applied 20+ impatient and lymphoid cell leukemias(ALL) at the CD with chronic and lymphoid cell leukemia(CLL), the researcher of MD Anderson recommends 20+ ALLs to apply Rituximab to cure for the old-age CD in the near future, 1 study as a result show:19s are big in 55 years old(medium the age be 66 years old) of CD 20+ ALLs applied Rituximab before each chemotherapy period and the CR rate was 63%, is existence rate 54% for a year.But the Rituximab apply at the clinical trial manifestation of CLL treatment:The alone applied effect not equal to Rituximab treatment filters a bubble lymphoid lump like, unless use big amount of.But consociation's chemotherapy and Rituximab effect then show Zhao very much, the most research adopt Rituximab+the blessing reach to pull strand.A big religion case II of MD Anderson expects to experiment manifestation Rituximab+the blessing reach to pull the strand/wreath Lin Mao An to cure 224 CLL reaction rates which haven't cured to attain 95%, CR rate is 71%.The treatment effect of way that other research groups requite slightly and almost, total of to say, add with the Rituximab have no CLL disease progress keep on time with total the existence rate have an exaltation.



Through several years of clinical practice and tally up, anti- CD 20 single anti-s are the ideal Ba of the 20+ lymphoid cell tumor of a treatment CD to the medicine, is filter the bubble lymphoid lump to contain special effect, but alone applied Rituximab of the effect be still not enough with complete clearance tumor cell, almost all filter a bubble a lymphoid lump patient at applied the Rituximab cure of not and meantime order to appear condition progress, appear to bear a medicine of main reason probably with filter the bubble lymphoid lump of the cell is tiny environment severity blemish but appear to the holdout of Rituximab various functionses.The measure which rectifies to bear a medicine can pass the living creature immunity of normal regulations a treatment an exaltation a Rituximab ADCC(the antibody dependent cell lie to lead of cell poison) effect or increment part of toxin or emanation kill wound function, such as applied small etc.s IL-12s for measure, regulate tiny environment(CpG application) and engineering antibody(the Ba is subjected to a body toward the Fc) and pit a vegetable to combine the application of the CD20 single anti-(the I131 － tositumomab and the Y90 － ibritumomab).Currently under way of the choice best － tositumomab of the usage I131 and Y90-ibritumomab treatment relapse with difficult cure to filter the bubble NHL project.



1.2 anti- CDs 52 single anti-s



The CD52 express in normal with the surface of malignant and lymphoid cell, greatly part of lymphoid cell leukemias immature cell expression CD52, the Alemtuzumab is a person of reorganization to turn anti- CD 52 single anti-s, already applied at the treatment of B-CLL, use an Alemtuzumab treatment progress to expect CLL and bear a medicine or relapse to the chemotherapy alone of the patient's reaction rate be about 33%-53% and respond to keep on medium time is 8.7-15.4 months.In the meantime, the Alemtuzumab has a certain function towards prepare behind differ of CLL(such as the chromosome imperfection or p of the No.11 or 1753 mutation etc.), if these result is further prospect experiment result affirm of words, can consider conduct and actions prepare behind bad CLL sufferer of a glimmer of treatment medicine.Moreover, the Alemtuzumab is after reach pull a strand treatment a blessing of make stronger a treatment can obviously improve reaction, attain member at parts of patients level of alleviate, have no disease to make progress existence time to obviously prolong.Lesson piece, the consociation chemotherapy cures CLL and can attain more ideal effect with effectively single nti-.The part for alone applied Alemtuzumab is difficult to cure ALL to have certain effect, some researches experiment of result recommendation at CD 52+ consolidation chemotherapies of ALLs if doubt a MRD circumstance, applied Alemtuzumab 30 mgs/time, 3 times/week, totally on all sides, subcutaneous injection.



For Alemtuzumab the applied clinical fulfillment be still more valid, total of to say is the clinical personnel considers lymphoid cell tumor Ba to cure of another the single anti- that can choose, have research concern to unite in the near future the project that two kinds of single anti-s(Alemtuzuma+Rituximab) and chemotherapy cure lymphoid cell tumor, if used for bear a medicine/difficult cure CLL of treatment, total the reaction rate is for 52%(the CR rate be 8%, PR is 44%), also needing to carry on more clinical trials then can more and completely evaluate the long-term effect of the treatment of its this kind of consociation.



1.3 anti- CDs 33 single anti-s



The CD33 is a Sui to fasten to build blood cell different film antigen especially, impatient expression CD33 of the Sui cell leukemia(AML) cell of 90% sufferers, anti- CD 33 single anti-s can with Ba to combine CD 33+ leukemia cells.The American FDA has been already grant and the anti- tumor anti-virus plain accidentally allied anti- CD of the calicheamicin the immunity of 33 single anti-s accidentally unites a thing(Gemtuzumab ozogamicin) to apply in relapse for the very first time and unwell proper carry on the old-age AML sufferer who strengthens a chemotherapy.The alone applied Gemtuzumab ozogamicin is the CR that the beginning starts inducement treatment for the old-age AML sufferer+the PR is 8%-23%.While thering are three researches show at strengthenning a chemotherapy in the young AML sufferer in the near future consociation application Gemtuzumab ozogamicin, can make the CR rate be up to 85%.A few IIIs of cooperation set expect to experiment to carry on at inducement chemotherapy unite the Gemtuzumab ozogamicin treatment beginning to diagnose AML.Because the AML cell lacks good surface different marking especially, the Ba has been a crux to the treatment, say currently, the CD33 is a more ideal Ba antigen, because of ago expect of the research show alone applied not and accidentally allied of the anti- leukemia of the CD33 single anti- the effect be weaker, Gemtuzumab ozogamicin of applied show certain foreground, thorough inquiry into it excellent turn application and develop it in the AML of treatment value is to have much of the necessary.



1.4 anti- VEGFs single anti-



The skin growth in the blood vessel factor(VEGF) presents in most tumor cells high expression appearance, the VEGF has incitement function in the propagate of leukemia cell, it high expression with prepare after badly related.The anti- VEGF single anti-(Bevacizumab) has already been prove to apply after the AML chemotherapy of safety.The II expects to experiment in relapse/ difficultly cure the AML, adopt a big the quantity ara-C(2 gs/m 2) to give a Mao Mao treatment with rice, and in the 8th day start applied Bevacizumab, CR rate is 33%, total reaction rate is 48%.It be an also likely to be another one way path which raises AML curative effect.



2, the Lao ammonia be sour to arouse Mao depressant



In the nasty and chronic Sui cell the leukemia, the Lao ammonia is sour to arouse a Mao mutation with activate very familiar, the Lao ammonia is sour to arouse Mao gene to belong to original cancer gene, its mutation and unusually activate to take place a development with tumor is near concern.In recent years, already its conduct and actions a tumor Ba is to the target of treatment, at applied the Lao ammonia is sour to arouse Mao depressant(the inhibitor of the tyrosine kinase) Ba toward the STI571(imatinib mesylate) which to ABL arouses a Mao activity cure a chronic grain a cell leukemia(CML) a sufferer to acquire better effect after, sour to different Lao ammonia arouse the research of the Mao depressant anti- tumor continuously has a new report way.More mature medicine in addition to outside also have FLT3(the tyrosine kinase of the FMS-like 3) to repress a thing etc. with AMN107 and BMS354825 of Imatinib function path likeness.These new medicines bear medicine CML, Ph to the Imatinib+ALL with relapse/difficult cure an AML I/II clinical trial to show certain curative effect.Still haven't a few be placed in a body to outside test or animal experiment stage of the Laos ammonias be sour to arouse Mao or Lao ammonia sour arouse Mao is repress by body thing etc. the Ba provided very important means toward the treatment for the Bas of blood tumor to the medicine.



2.1 Imatinib



The Imatinib(STI571, Gleevec, space row Wei) is the first small member that success Ba arouses Mao toward the ABL to repress a thing, make the CML treatment produce revolution a change, apply a standard the Imatinib(400 mgs/day) treatment for measure in the early hair the chronic the period the CML and more than 80% patients can attain complete cell genetics to alleviate(CCR).For interferon treatment the CML patient of failure, the Imatinib treatment equally has good effect.Imatinib conduct and actions aims at a Lao ammonia later on sour arouse Mao an activity to repress a thing to also start being try apply in other leukemias and some entity tumorses.Particularly is to the Ph+ALL treatment, also start carry on the on trial research of Imatinib application.The applied Imatinib treatment relapse/difficult cure Ph+the ALL I-II period experiment a manifestation and attain to alleviate or clearance outside week cell with immature blood is 66%, 19% attains CR, but reaction continuously time be very short.If cure Imatinib and inducement and consolidation a consociation application, then can obviously raise an anti- leukemia an effect.The II period studies consociation Imatinib(1-14 day) a project with high CVAD chemotherapy, 96% Phs+ALL the patient equally cures 21 days attain CR, 5/26 attain member level CR.Another a project are after inducing a chemotherapy for a week to start keep on application Imatinib and apply Imatinib while make stronger treatment+MTX/ara-C, the CR rate reaches to 95%, and is cure 2 months attain member level CR, a year have no the existence rate of disease with total existence rate is 78% and 88%.For the old-age Ph+ALL, lay claim to alone applied Imatinib(or strengthen of loose), Germany and Italian etc.'s results of a few research group report way all give satisfaction, the CR rate attains above 90%, but applies the Imatinib treatment old-age Ph+the ALL still has no the project of standard, have already applied a 600 mgs/day and have already applied a 800 mgs/day as well+strong loose treatment, also need the further clinical trial to provide data.Moreover, have already discovered Imatinib to express C-KIT of the AML patient have a certain function.



The Imatinib all has good effect in the treatment the CML and later on apply to the Lao ammonia sourly arouse the related disease that the Mao activity increases Gao, though the Imatinib has in repressing a Lao ammonia sourly arousing Mao lively very high early start an effect, and can nicely is bear by patient to be subjected to, clinical up relapse of the case also continuously increases, also in the meantime have parts of patients can't bear to be subjected to Imatinib.So, bore Imatinib medicine mechanism and processing measure etc. to carry on more thorough research in the near future.Bear a medicine to the Imatinib mainly is to arouse Mao area what mutation cause, there is the one who think to arouse a Mao area's mutation to bear a medicine to the part passing the increment Imatinib treatment quantity but overcoming, apply a 800 mgs/day of experiment under way medium.In addition, the related new medicine also continuously turns into a clinical stage.



2.2 AMN107



The AMN107 is a kind of ammonia Ji Mao Ding, is a derivatives of new Imatinib structure.Similar to Imatinib, the AMN107 puts out to live a form to combine by Gou elephant to arouse Mao area at the ABL, its function effect about is an Imatinib of 2500%.That medicine mainly to Imatinib bears medicine but design.The I expects to experiment to used for the acceleration period that the Imatinib bears a medicine with nasty change to expect CML and Ph+ALL patient.The applied AMN107 cures 50 Imatinibs to bear medicine acceleration to expect CML, 24 Sui cells impatient change CML and 10 Phs+ALL result manifestation, the complete hematology alleviate(CHR) to distinguish to 51%, 11% and 10%.Also start applied AMN107 cure in the near future chronic period the Imatinib bear medicine CML, 15 CHRs which cure a patient attain 80% and moreover also start being relapse/difficult cure Ph+the ALL experiment application.Bear medicine CML to the Imatinib, the AMN107 is doubtless a new hope, the clinical trial is as a result still limited currently and still need further summary that medicine usage of the best project with attain better curative effect.



2.3 BMS354825(Dasatinib)



The Dasatinib is the An medicine of a Mao Shi Mi Shi Zui Mao, its structure and Imatinib to have no relativity, mainly combine by openning a form ABL to arouse Mao area and also have to repress SRC household to arouse a Mao function in the meantime.Clinical ago study to show that it represses an activity to invite for the Imatinib of 30000%, bear the medicine cell of mutation to all have to repress a function to almost all Imatinibs.Started the treatment Imatinib of the first adoption Dasatinib bearing a medicine or can't bear to be subjected to Imatinib chronic period CML a plan in 2003, 31 Imatinibs bore medicine CML the CHR of the case for 84%, 8 CHRs that can't bear to be subjected to an Imatinib case is 100%.The I expects the acceleration period that the clinical trial also useds for Imatinib to bear a medicine or can'ts bear to be subjected to Imatinib later on with nasty change to expect CML and Ph+ALL, 10 accelerations expect CML, 34s nasty change or Ph+the ALL patient's CHR distinguish to 50% and 28%, the Dasatinib also starts being relapse/difficult cure Ph+the ALL experiment application.



Expected to test manifestation Dasatinib to arouse repress of Mao an activity to the ABL ago far far high at the Imatinib, but haven't study result compared both in the effect on the application and bore medicine and toxicity gradation difference, currently main of experiment the point still lie in the application which to Imatinib bears a medicine a patient up.



2.4 The FLT3 represses a thing



The FLT3 almost is express in all AMLs in, it the composing activate mainly is because the film combines area in of inside establish sex replication or arouse Mao to activate the mutation(about is take place in 30% AMLs in) of wreath, should discover urged FLT3 a clinical research of repress the thing.The FLT3 which carries on a clinical trial currently represses a thing to contain 4, MLN581 and SU11248, four all can nicely Ba to repress FLT3, but the clinical reaction be more gentle, generally only it is thus clear that arrive it outward week the immature cell of the blood and marrow contain decrease function, 1 that is in the near future experiments a manifestation, the FLT3 represses a thing treatment and can make 70%(40/57) patient the Chinese and Foreign week cell with immature blood reduce above 50%, but only have 6 patient the immature cell of the marrow to reduce above 50%.Past the point studied currently be the consociation application that the FLT3 represses thing and chemotherapy.



3, method Ni the Ji transfer Mao to repress a thing



The method Ni Ji transfers Mao(Farnesyl tranferase) to lie method Ni Ji of lead the RAS household to turn but makes it activate, the RAS gene household has in the importance of signal conduction and propagate regulate the thoroughfare important function, but the occurrence of the RAS gene mutation and Sui leukemia exist certain relativity, parts of leukemias and MDS patient the RAS gene order a mutation.The method Ni Ji transfers Mao to repress a thing(FTI) to pass in advance the RAS method Ni Ji to turn but interference RAS signal and it transfers blood plasma.FTI to difficult cure or beginning hair AML and tall patient of Wei MDS all has curative effect.But its reaction effect and patient whether the existence RAS's gene's mutation is irrelevant.Currently, the method Ni Ji transfers Mao to repress the thing Tipifarnib has already experimented an application in AML and MDS the patient.Cure 148 CRs that beginnings deliver old-age AML(medium the age be 73 years old)+the PR is 34%.(CR is 18%)The II expects to experiment evaluation Tipifarnib to used for the circumstance of old-age AML patient that can't carry on a chemotherapy, and random the research used for relapse and have a high CR possibility of unwell proper carry on building the blood stem-cell transplantation of AML patient, the application of medicine is make stronger chemotherapy juniors to go and study under way medium, there is still no result.But in the MDS II period study already some result report way, two sets of report way distinguishes to 3/27 and 28/82 tall patient of Wei MDSs have reaction to the treatment and attain CR distinguish is 2 and 6.In fine, FTI for some difficult cure AML and MDS is a kind of treatment meanses that lately can choose.



4, the Diao Wu related egg white repress the Ba of thing toward the treatment strategy



The Ba of 4.1 anti- IAP household egg whites studies toward the medicine



The IAPs(the apoptosis proteins of the inhibitor of, the egg white of Diao Wu represses a thing) is the household member whom the Caspase represses a thing, it can and Caspase3、7 with 9 combine and repress it activity, stop the performance period of Diao Wu.The IAP household egg white has common BIR(the repeated sequence of the pole form virus IAP) area, the IAP that authenticate already in the mankind has 8 kinds at least, among them, the XIAP(X-linked IAP) be plain(survivin) with existence is most for being a Ba of concern to cure of purpose gene.The XIAP is a NF-к the B activate factor and relate to the dynamic equilibrium of copper, but exist a vegetable to repress Caspase a function weaker, but it may be a cell period the progress and mitotic 1 regulate factor.The IAPs(such as XIAP and existence vegetable) super expression can become to various holdouts of chemotherapy medicine and knock outside body in the cell development in addition to XIAP and exist plain gene can induce cell Diao Wu and converse to bear a medicine.So aim at IAPs Ba probably be able to improve the patient's treatment effect toward the treatment.



Have already designed more successful anti- XIAP and the anti- righteousness nucleic acid of existence vegetable already currently, both are outside body and all have inducement Diao Wu and to build up to the function of chemotherapy sensitivity inside body.Animal experiment shows that they can defer to transplant the growth of tumor inside body, but to normal cell-free toxicity function of adult's cell, this has something to do with normally cell lacking the sensitivity to repress the thing to IAPs.In the near future, the Ba has already carried on an I period clinical trial in England toward the anti- righteousness nucleic acid of the XIAP and the existence vegetable, and observe it as single medicine apply in difficult cure sex malignant tumor of effect.



In addition also there is the small member that the research releases XIAP repressing a thing, it can stop activate of IAP egg white part, have already produced the first small member which represses XIAP to repress a thing currently, mainly is what the part which aims at its BIR2(combine and repress Caspase3 with 7) with BIR3(combine and repress Caspase9) design, prove its inducement cell Diao the function of the Wu in the experiment research of parts of AML patient's samples, and is consider that the application is at the clinical research.In order to repressing Caspase and stopping to the understanding shortage which exists vegetable structure and it ， the mitotic mechanism still not and very understands and and is hard to design a suitable small member to repress a thing currently.



4.2 be suffused with a plain egg white Mao body to repress a thing



A great deal of egg white water of true pit cell solution intermediation passes to be suffused with plain egg white Mao body path(Ubiquitin proteasome pathway, UPP) but carries out.The egg white declines a solution to have to many important cell functions a decisive function and arouse the in time decline of the Mao solution etc. during the period of having a silk abruption such as egg white and the egg white dependence of the cell period of the cell period.At the beginning pass a body to outside synthesize some probes which to egg white decomposition live a sexual function to the research which is suffused with a plain egg white Mao body to repress a thing, they combine sour at the only Su's ammonias which activate part of be suffused with plain egg white Mao body second unit.The main product is a PS-341(be called Bortezomib or Velcade now?), It has to induce Diao Wu and anti- tumor activity, can repress the NF-к B pit to transcribe and lower marrow lump cell sticky attach the expression of factor, interference sticky attach to lie to lead of the IL-6 be born.Return the ability interference MARK thoroughfare to lie to lead in the meantime of propagate signal, induce the egg white dependence of the cell period to arouse Mao to repress a focuse of the thing p 21 Cip1s and the p 27 Kip1s.The Bortrzomib has already got into an I-III period clinical trial currently, I period's test mainly is apply in to deliver sex marrow lump(MM) more with the non- Huo strange gold lymphoid lump(NHL), and the II expects many center research a manifestation:The Bortezomib treatment MM relapses the patient's(among them 91% bears a medicine to the treatment in past) total reaction rate as 31% and 10% attains CR or close CR.Medium respond to keep on time as 12 months, total existence rate is 16 months.The II expects the NHL treatment to experiment the research has already carry on as well, in relapse/ difficultly cure of filter the bubble, edge area and the mode lymphoid lump of total and efficient is or so for 58%.The international III cured in the MM expects a clinical trial is more alone applied Bortezomib or ground fill a rice loose cure 669 to relapse/difficult cure MM a patient of effect, result manifestation application Bortezomib set and ground fill a rice loose set comparison, total reaction rate is 38%:18%, the disease makes progress time as 6.2 months with 3.5 month ∶s, a year always existence rate's ising 80% ∶s be 66%s.Further of research is how unite application Bortezomib and other medicine to cure a MM patient, already recommend allied use mildewed vegetable, the immunity regulate medicine, Ma3 Fa3 Lan2 and steroid etc..Among them Bortezomib+ mildewed vegetable showed obvious effect, is relapse/difficult cure the total reaction rate in the MM as 73%, CR and close CR is 36%, currently already start an III period experiment.Moreover will should cure a project application a beginning hair MM inducement under medical treatment, total reaction rate is 80%.



Owing to repress to be suffused with plain egg white Mao's way of the body can availably pass NK-к B and converse a circumstance of bear the medicine, many researches are constantly also developping new medicine, the best research is a concerning hot shock egg white(HSP), it is a type of egg white which passes to be suffused with a plain egg white Mao body to repress path but activates, it is a keep company with of cell egg white, involve many regulate Diao Wu thoroughfare etc..



4.3 The outcome expression of the household BCL-2 regulates a research



The household BCL-2 gene is important cell existence factor, it has in the regulate of mostly inside thoroughfare of Diao Wu with the execution important function.Can is divided into 3 sets according to household BCL-2's circumstance of the BCL-2 together original area(BH) contain by member, the member of anti- Diao Wu:(include 4 BH areas)BCL-2, BCL-XL, BCL-w, MCL-1 and A1, ex- member of Diao Wu:(include 1-3 BH areas)BAX and BAK, and different ex- egg white of Diao Wu related member:Like BID, BAD, BIM, BIK, PUMA, NOXA...etc..In the tumor biology, because of the complexity of household BCL-2 egg white, included several household members to express of up adjust, influenced many of the different household member to regulate path, so have a research to think that the design whole BCLses repressing a thing is very necessary.The ABT-737 is a BH3 rightness that can combine BCL egg white to connect the small member medicine in the ditch and repressed the function of BCL-XL, BCL-2 and BCL-w thus.Have already started to prove about anti- tumor an activity in the animal the experiment currently.The GX15-070 is the small member medicine that the another represses BCL household egg white, it can combine and repress BCL-w, BCL-XL and MCL-1, but activate ex- egg white of Diao Wu like the BAX and the BAK.Currently GX15-070 already applied in relapse/difficult cure a CLL I period experiment.



In the lymphoid cell tumor, it is familiar to involve the chromosome easy of genes BCL-2s, like t(14;18)occurrence in 85%ly filter the bubble lymphoid lump with 20% DLBCLs, cause gene BCL-2 the apposition is at the regulate of the heavy chain(IgH) gene of the immunity globulin component under, became transcribe of BCL-2-IgH origin and the super expression of BCL-2.Past pass next adjust the expression of BCL-2 but regulate the cell Diao Wu thoroughfare is a Ba which to these lymphoid lumps cures to cure strategy.The new medicine cured according to the anti- lymphoid lump of BCL-2 includes lately small member, advantage Mao segment and puts together to connect Mao with anti- righteousness nucleic acid's etc.'s strategy Be already used for choosing suitable egg white of anti- Diao Wu in.In the AML, high expression BCL-2 with badly prepare after related, making use of the BCL-2 anti- righteousness nucleic acid a bottom to adjust AML cell can increase AML cell's sensitivity for chemotherapy.The I of applied BCL-2 anti- righteousness nucleic acid(Genaense, GNS) expects the clinical trial to show reaction in 8/20 relapse/ difficultly cure the AML.Another I expects to experiment to then evaluate it to unite applied effect with chemotherapy, 10/26(45%) patients attain CR.III's expecting to experiment is evaluate it participates inducement to alleviate with make stronger a treatment of consociation function.



The Ba of BCL-2 and genes BCL-6s or egg white is a point that this next year will discuss toward the treatment, regardless continue to educate, be still science report and study thesises to all haven't a few foundations and applied contents which involve that aspect, conduct and actions is an important path which induces the tumor cell Diao Wu, the Jie anti- BCL-2 may be the points which develop related medicine in the near future with BCL-6.



4.4 Bas cure toward the genes BCL-6s



The genes BCL-6s code of transcribe and repress factor is living the B cell in the hair center divide of necessary factor.It has in living the formation of hair center, divide stop with the lymphoid lump the formation etc. the process key function.Come from the B cell which livings hair center lymphoid lump often high express BCL-6, mainly is because the chromosome easy and ordered a mutation to change regulate of the BCL-6 start son but cause, the expression maladjustment of BCL-6 is familiar(40%) in the DLBCL, and can induct DLBCL in the small rat model.In the near future study to discover next adjust the expression of BCL-6 can increase DNA harm level, the BNHL which hints to keep on to express BCL-6 may have the function that the decrease Diao Wu and DNA hurt, so the Ba of BCL-6 to cure, put out to live genes BCL-6s, is a treatment strategy which has an attraction.There is research designing 1 to BCL-6 repressing sex compound especially different Mao segment(BPI), it can stop the BCL-6 compound formation, repressed the expression of the related gene(SMRT, N-CoR and BcoR) of downstreams BCL-6s, repressed to living the formation of hair center thus, its function result and BCL-6 lack of the form type of the animal likeness.It is design a BPI application at the project of the B cell lymphoid lump patient's clinical trial currently.



In fine, along with to thorough understanding and member living creature and the technique development of immunology of tumor outbreak mechanism, valid of Ba to with the immunity cure medicine to pile up one after another, contain count for much meaning towards improving the treatment effect of the blood tumor, is also currently numerous researchers pay attention to of important direction.