Be worth of the mammary glands cancer endocrine treatment

The mammary glands cancer outbreak rate is keep on ascension, but because of now make a diagnosis and give treatment in time, the death rate has to descend.The mammary glands cancer is a kind of whole body disease, the whole body treatment is an important means, and the whole body assistance treatment can lower to relapse with the risk of the death.The mammary glands cancer endocrine treatment is one of the method of whole body treatment and prevent°from relapse to transfer after the mammary glands cancer of Shu of the assistance cure and relapse to transfer after of give relief to treatments to all have a very important position.The curative effect of the endocrine treatment and the estrogen of the sufferer's ising subjected to a body(ER) is been near concern by body(PR) condition with Yun hormone.According to American Bethesde meeting comprehensive international community more than 400 various way of hormone treatment report express, haven't yet hormone is cure by the mammary glands cancer case endocrine that the body measurese of efficient is 30%;ER male sufferer's being efficient is 50% ～s 60%;ER feminine gender sufferer's being efficient is 5% ～s 8%;The ER, PR all male of as efficient as 70%.



The endocrine cures a method

1.anti- estrogen medicine.Three benzene oxygen the An(Tamoxifen TAM he the aroma of Mo Xi) be the most in common use anti- estrogen medicine currently, with female two the Chun competition mammary glands cancer cell surface of the estrogen be subjected to a body and make cancer cell the stagnation expects at the G1, the protein which represses estrogen dependence synthesize and reduce propagate of cancer cell.Three the benzene oxygen An anti- tumor the function be also relevant with other mechanisms, if pass to lower film transparence, can reduce to transfer Mao this cancer to transfer accelerant of born, make the cell combine the part rigid to build up, keep the incursion of tumor cell from transfer thus;Because the film transparence lower, on the cell membrane various Mao, be subjected to the activity of body and passage to also descend, make protein's synthesize be suppress and repress cancer cell a growth thus.May also pass to repress the tumor new-born blood vessel formation and raise the machine body cell immunity's level's etc.'s mechanism to attain to repress a mammary glands cancer cell growth of function.Three benzene oxygen the An is lent support to the standard medicine of endocrine treatment after lend support to cure meeting recommendation as all mammary glandses cancer that the hormones are subjected to body masculine gender, patient Shu by mammary glands cancer in the American national health, graduate school(NIH) in 2000.Take orally after show the Shu according to the EBCTCG research three benzene oxygen the An make ER for 5 years male mammary glands cancer the sufferer relapse rate and death rate to distinguish for 5 years opposite reduce 47% and 26%.The estimate have over 400000 survive at present of the women receive benefit in three benzene oxygen the treatment of the An, much more millions of the women expect the aspect to benefit without the disease existence at the extension.The ASCO meeting suggests in 2002:Three benzene oxygen An treatments for 5 years still keep aring the standard projects that the mammary glands cancer assistance endocrine that the hormone is subjected to body masculine gender cure currently.Three benzene oxygen An poisonous pair reactions have been already have fever, the face tide be red, anorexia, disgusted, the increment blood bolt formation, vagina to bleed and the secretion, labium scratch an itch, have irregular menses, the womb muscle lump and cerebral disease, accidentally have the report way the complications that can take place ophthalmology.Take three benzene oxygen Ans over a long period of time, probably increase the risk of film cancer occurrence inside the womb, this kind of sufferer should carry on at least annually 1~2 second son temple the B be super or inside the film live check, and to that medicine probably exist of potential danger exaltation vigilance.Use three benzene oxygen when the An carries on an assistance treatment to the mammary glands cancer, people discover three benzene oxygen the An delivers a mammary glands cancer to contain prevention function at first to the second.It is the first is grant by the FDA of use to reduce to cut off through in front and back mammary glands cancer women the tumor chemistry of high Wei factor prevent°from medicine.

Giving a Rui rice aroma(Fulvestmnt, method joy) is three benzene oxygen the derivatives of the An, the main metabolism distributes in the lung in the liver, as a result to film inside the womb and liver influence smaller, transfer to the lung of the function be better.Give a Rui rice aroma to compare three benzene oxygen the An show Zhao to lower the cell membrane top ER amount towards being have by body higher affinity, can, there is no estrogen kind function, is called "pure" anti- estrogen kind medicine.It is unique by the new choice of the juniors defer mammary glands cancer sufferer.Research result enunciation to since go toward endocrine treatment failure of later period mammary glands cancer sufferer, can consider that the usage gives a Rui rice aroma.

2.the fragrance turn Mao depressant.The function synthesizes male hormone to finally convert into the one step of estrogen at the steroid and stop male Xi two Tongs Be turned Mao's fragrance to become female two Chunses by fragrance, stop Gao Tong a conversion for the female Tong.The ammonia Lu rice is especially the fragrance which developped at the earliest stage to turn Mao depressant(AG) and mainly used for to cut off through empress later period mammary glands cancer of treatment, its particularity isn't strong and cause completely repress of the adrenal glands function, side effect more big, have weariness, love to sleep, faint, disgusted, vomit etc., the clinical application is subjected to restriction, in recent years already drive new of the non- Zi body fragrance turn Mao depressant to replace.Clinical in common use and the third generation fragrance turns Mao depressant currently, it only to unique through empress women are valid.BE responding to the hormone treatment of transfer the women's endocrine under medical treatment of the sex mammary glands cancer, the third generation fragrance turns Mao depressant to be think and can used for a glimmer of or two lines treatment.

The Anastrozole(Arimidex, Rui rather get) is the fragrance of the new development to turn Mao depressant, often Be later period or relapse sex mammary glands cancer of two line treatment medicine.The ATAC in earlier period experiments a result a hint Anastrozole compare three benzene oxygen the An be better to expect without the disease existence and can lower cancerous to the side mammary glands of incidence rate.The Anastrozole is used for hormone by the FDA approval to be subjected to body masculine gender recently of unique through empress earlier period mammary glands cancer the lend support to of women cure.

Letrozole pharmacology the characteristic be similar to Anastrozole, the 39th ASCO annual convention with the 12th European tumor conference(ECCO) to Letrozole of lately lend support to a report way of cure many center clinical trials(P024) before the Shu, and 12 ECCOs used for the report way of many center clinical trials(P025) of the mammary glands cancer a glimmer of treatment in later period to hint that the Letrozole curative effect shows Zhao to surpass to the Letrozole three benzene oxygen An.Moreover 12 ECCOs think according to several Letrozole of the clinical trial results not only in the later period mammary glands cancer of the under medical treatment have advantage and lend support to a prevention to relapse to transfer aspect to surpass after the mammary glands cancer of Shu three benzene oxygen An and bad reaction little.

3.Yun Tong.The Yun Tong medicine represses secrete of the egg bubble estrogen and yellow body hormone through a negative feedback function, reduce the creation of ovary estrogen, pass to repress the secrete of hormone of the Cu adrenal glands skin quality, the creation of estrogen in the decrease adrenal glands skin quality, compete sex to repress male two Chuns and combine of ER after being combine by body with Yun hormone, end decrease the estrogen secrete.Another can pass arrestment ER etc. develop the anti- mammary glands cancer function at savings in the cell nucleus.Mainly there is A Yun Tong(A Qian Yun Tong, MPA) with A ground Yun Tong(MA).

MPA to unique through in front and back, the sufferer of ER and PR double masculine gender valid, but because the side effect more and greatly and generally doesn't do the assistance treatment of mammary glands cancer, but Be much used for improving appetite, increase to put on weight, protection marrow, exaltation chemotherapy's bear is bear by sex, TAM medicine sufferer, transfer to relieve pain effect to the bone better than TAM.

Some clinical trials show recently Letrozoleyu and Anastrozole are better than A ground Yun Tong(MA)'s curative effect and the weight increment be little.

4.Cu sex gland the hormone release the hormone similar thing(LHRHa).Extremely Be descended a Qiu brain to secrete Cu sex gland hormone to release hormone(LHRH) by ex- women, with hang the body cell membrane up corresponds to be subjected to a body knot larynx, make to hang a body to release Cu sex gland hormone(LH, FSH) and the function also releases estrogen and Yun hormone at the ovary.The brain hangs body Cu sex gland to release the hormone similar thing(LHRH － a) Ge to give up Rui a wood(Goserelin) currently extensively applied in unique through ex- mammary glands cancer sufferer, opposite at the methods, such as chemotherapy and ovary emasculation...etc., this is efficiently 1 kind and the poisonous pair respond small endocrine a treatment medicine.

The Ge gives up the Rui wood's merchandise to be named Zoladex, the vice- reaction is mainly a hot and dry, sexual function change, the minority can have the brain disease the mutation, the disgusted and white cell reduce etc.;Still have a pair reaction is to go against sex to stop menstruating.

The GNRH similar owner wants to used for the later period sufferer who cuts off through the front or rounds unique menstruation, the Ge gives up Rui a wood to unique through empress the case then is mostly invalid.The Ge gives up Rui and wood's hasing already been confirm improve to cut off to prepare rear noodles' curative effect through the ex- women can compare with chemotherapy.

5.ovary excision and ovary put to treat emasculation.The ovary excision emasculation is applicable to cut off through former sufferer of later period, the ER(+) is better with PR(+)'s curative effect, efficient and 30% ～s 50% be or so.The ovary puts to treat emasculation to often take a few months to attain ovary function to completely repress.Because of these two kinds of method side effect more big, the clinical few adoption was act for by the medicine emasculation gradually of trend.



The new ssistance endocrine cure

BE to don't transfer a sexual mammary glands cancer, the whole body cured a headway line at the applied part, system endocrine treatment.Mainly is an ER(+) of unique through the future trouble.The clinical research discovers that the biggest curative effect that the new assistance endocrine cure usually appeared in early days 3 around months are after cure, so its treatment keep on time is 3 months, but ideal of treatment continuously time was still not explicit.New assistance endocrine treatment ability with new assistance the chemotherapy be similar and provide an opportunity of reserve the breast for the sufferer who may need to go mammary glands resection;New assistance the endocrine treatment can also provide tumor hormone the data of the sensitivity, valid instruction Shu behind lend support to a treatment.The in common use medicine has three benzene oxygen Ans, the third generation fragrance to turn Mao depressant(Letrozole, Anastrozole), new anti- estrogen medicine(Faslodex).Empress twos show in the clinical trial of the curative effect be obviously high in three benzene oxygen An.



Lend support to an endocrine treatment

To ER(+) with PR(+)(or), and be subjected to a body circumstance unidentified sufferer, ignore whether the age, lump size, menstruation condition, armpit lymphoid knot is invade or not, should go assistance endocrine to cure.But for the age<35 years old.
After the mammary glands cancer occurrence transfer, chemotherapy and endocrine's cure can choose to use.Exist the hormone is subjected to the sex mammary glands cancer of the transfer of body sufferer, under the sistuation that have no merger to quickly develop, the suggestion head chooses an endocrine treatment but isn't a chemotherapy.



Unite an endocrine treatment

Can raise curative effect to still have no explicit conclusion for endocrine cure medicine unite cure, so don't recommend to unite endocrine medicine a treatment to used for the mammary glands cancer assistance endocrine a treatment currently.

The mammary glands cancer endocrine cures continuously publish of the new medicine and increase of applied method and make the value of the endocrine treatment mammary glands cancer more and more get a value.People are investigate new treatment strategy, such as concerning unite with Ba toward the medicine with preface Guan applied problem research, three benzene oxygen An and the third generation fragrance turn Mao depressant preface Guan application study, the third generation fragrance turn Mao depressant and lend support to a chemotherapy to unite an applied method research an etc., these success that research will have instruction function for the endocrine treatment of mammary glands cancer, ability further improvement the mammary glands cancer sufferer's living quality and extension exist a period.